18113-21-8

Basic information

• Product Name: Phenol, 2-chloro-3,5-dimethoxy-
• CAS NO: 18113-21-8
• Molecular Formula: C8H9ClO3
• Molecular Weight: 188.611
• Mol File: 18113-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phenol, 2-chloro-3,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-chloro-3,5-dimethoxy-(18113-21-8)
• EPA Substance Registry System: Phenol, 2-chloro-3,5-dimethoxy-(18113-21-8)

Safety Data

• Hazardous Substances Data: 18113-21-8(Hazardous Substances Data)

Usage

General Description

Phenol, 2-chloro-3,5-dimethoxy- is a chemical compound that is a derivative of phenol with chlorine and two methoxy groups substituted at the 2 and 3 positions, respectively. It is used as a building block in the synthesis of various pharmaceuticals and organic compounds. Phenol, 2-chloro-3,5-dimethoxy- has been studied for its potential pharmacological properties, including as an antioxidant, anti-inflammatory, and antifungal agent. It also has potential applications in the development of new drug candidates and in the field of organic chemistry for chemical synthesis. However, it is important to handle this chemical with caution due to its potential health hazards and proper safety precautions should be observed when working with it.

Upstream product

• 500-99-2 3,5-dimethoxyphenol 
• 621-23-8 1,2,3-trimethoxybenzene 

Downstream Products

• 81325-85-1 3'-chloro-2'-hydroxy-4',6'-dimethoxyacetophenone 
• 72565-72-1 2-chloro-1-(3-chloro-2-hydroxy-4,6-dimethoxy-phenyl)-ethanone 
• 130900-85-5 7-Chloro-4,6-dimethoxybenzofuran-2,3-dione 
• 6468-53-7 2-hydroxy-2',4,4',5',6-pentamethoxybenzoin 
• 131939-10-1 Acetic acid 2-chloro-3,5-dimethoxy-phenyl ester 
• 47610-29-7 1-<2-Chlor-3.5-dimethoxy-phenoxy>-4-benzyloxy-cyclohexan-carbonsaeure-(1) 
• 92651-17-7 1-<2-Chlor-3.5-dimethoxy-phenoxy>-cyclohexan-carbonsaeure-(1) 
• 93089-31-7 1-<2-Chlor-3.5-dimethoxy-phenoxy>-2-methoxy-cyclohexan-carbonsaeure-(1) 
• 72545-41-6 2',4',5,5',7-pentamethoxyisoflavone 
• 136616-28-9 1-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-ethanone 
• 136616-32-5 2'-hydroxygriseofulvin 
• 136616-29-0 3-[3-Chloro-4,6-dimethoxy-2-((E)-(S)-1-methyl-but-2-enyloxy)-phenyl]-3-oxo-propionic acid methyl ester 
• 136616-31-4 (R)-7-Chloro-4,6-dimethoxy-2-((E)-(R)-1-methyl-but-2-enyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester 
• 136642-41-6 (R)-7-Chloro-4,6-dimethoxy-2-((S)-1-methyl-2-oxo-ethyl)-3-oxo-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester 

Relevant articles and documents

Sulfoxide-Promoted Chlorination of Indoles and Electron-Rich Arenes with Chlorine as Nucleophile

An efficient chlorination of indoles and electron-rich arenes with chlorine anion as nucleophile is described. With the use of ethyl phenyl sulfoxide as the promoter, the reaction went smoothly under metal-free and mild conditions. Various indoles and electron-rich arenes are converted into the corresponding chlorinated compounds in moderate to excellent yields. A plausible interrupted Pummerer reaction mechanism was proposed without the oxidation of chloride anion. In addition, the byproduct thioether could be easily converted to the starting material sulfoxide just by a simple oxidation reaction. (Figure presented.).