183155-67-1

Basic information

• Product Name: 3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether
• Synonyms: 3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether
• CAS NO: 183155-67-1
• Molecular Weight: 584.5
• Mol File: 183155-67-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether(183155-67-1)
• EPA Substance Registry System: 3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-iodobenzyl ether(183155-67-1)

Safety Data

• Hazardous Substances Data: 183155-67-1(Hazardous Substances Data)

Upstream product

• 146285-52-1 (4-bromobenzyl)-2,2,2-trichloroacetimidate 
• 53958-94-4 3-(1H-imidazol-4-yl)propionic acid methyl ester hydrochloride 
• 76-83-5 trityl chloride 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 589-17-3 p-bromobenzyl chloride 
• 183155-66-0 3-<1-(triphenylmethyl)imidazol-4(5)-yl>propyl 4-bromobenzyl ether 
• 102676-60-8 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanoic acid methyl ester 

Downstream Products

• 152028-96-1 iodoproxyfan 

Relevant articles and documents

Iododestannylation: An Improved Synthesis of Iodoproxyfan, a Specific Radioligand of the Histamine H3 Receptor

Iodoproxyfan, a specific radioligand of histamine H3 receptors, was synthesized in 60percent yield under very mild conditions from a tributylstannyl precursor.The arylstannane, which was obtained in a palladium-catalyzed reaction of arylbromide and hexabutylditin, smoothly underwent radioiodination with sodium iodide and chloramine-T to give tritylated iodoproxyfan.Final detritylation was achieved with formic acid 90percent at room temperature.Compared to the original copper(I)-mediated halogen exchange this procedure has major advantages in terms of cost and ease of use. - Key Words: Iodine-125; iododestannylation; iodoproxyfan; histamine H3 receptor antagonist.