183305-24-0

Basic information

• Product Name: N-[2-[5-(Aminoiminomethyl)-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-3,5-difluoro-4-pyridinyl]-N-methylglycine
• Synonyms: Fidexaban;N-[2-[5-(Aminoiminomethyl)-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-3,5-difluoro-4-pyridinyl]-N-methylglycine;CI 1031;ZK 807834;Glycine, N-[2-[5-(aMinoiMinoMethyl)-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-Methyl-1H-iMidazol-2-yl)phenoxy]-3,5-difluoro-4-pyridinyl]-N-Methyl-
• CAS NO: 183305-24-0
• Molecular Formula: C25H24F2N6O5
• Molecular Weight: 526
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 183305-24-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 635.4 °C at 760 mmHg
• Flash Point: 338.1 °C
• Appearance: /
• Density: 1.48
• Vapor Pressure: 5.15E-17mmHg at 25°C
• Refractive Index: 1.664
• PKA: 3.25±0.10(Predicted)
• CAS DataBase Reference: N-[2-[5-(Aminoiminomethyl)-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-3,5-difluoro-4-pyridinyl]-N-methylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-[5-(Aminoiminomethyl)-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-3,5-difluoro-4-pyridinyl]-N-methylglycine(183305-24-0)
• EPA Substance Registry System: N-[2-[5-(Aminoiminomethyl)-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-3,5-difluoro-4-pyridinyl]-N-methylglycine(183305-24-0)

Safety Data

• Hazardous Substances Data: 183305-24-0(Hazardous Substances Data)

Usage

Uses

A direct inhibitor of factor Xa (FXa); anticoagulant. It has been shown to reduce ex-vivo arterial thrombus formation and factor-X activity in a dose-dependent manner.

InChI:InChI=1/C25H24F2N6O5/c1-33-8-7-31-23(33)14-3-2-4-15(9-14)37-24-20(26)16(11-30-12-19(35)36)21(27)25(32-24)38-18-10-13(22(28)29)5-6-17(18)34/h2-6,9-10,30H,7-8,11-12,28-29H2,1H3,(H,35,36)

Upstream product

• 17345-61-8 3,4-dihydroxybenzonitrile 

Relevant articles and documents

Discovery of N-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-3,5- difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy] pyridin-4-yl]- n-methylglycine (ZK-807834): A potent, selective, and orally active inhibitor of the blood coagulation enzyme fac

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