18386-45-3

Basic information

• Product Name: 3-hydroxyandrost-4-ene-6,17-dione
• Synonyms: 3-hydroxyandrost-4-ene-6,17-dione
• CAS NO: 18386-45-3
• Molecular Formula: C19H26O3
• Molecular Weight: 0
• Mol File: 18386-45-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 193-196℃
• Boiling Point: 479.1°Cat760mmHg
• Flash Point: 257.6°C
• Appearance: /
• Density: 1.19
• Vapor Pressure: 3.44E-11mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 3-hydroxyandrost-4-ene-6,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxyandrost-4-ene-6,17-dione(18386-45-3)
• EPA Substance Registry System: 3-hydroxyandrost-4-ene-6,17-dione(18386-45-3)

Safety Data

• Hazardous Substances Data: 18386-45-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H26O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,11-14,20H,3-8,10H2,1-2H3/t11-,12-,13-,14-,18+,19-/m0/s1

Upstream product

• 54604-81-8 5-bromo-3β-hydroxy-5α-androstan-6,17-dione 3-acetate 
• 4229-69-0 3β-acetoxy-5-bromo-6β-hydroxy-5α-androstan-17-one 
• 115350-45-3 C₂₃H₃₄O₅ 
• 14456-20-3 3β-acetoxy-5-androsten-17-one-17-ethyleneketal 
• 39933-10-3 3β,5-dihydroxy-5α-androstane-6,17-dione 3-acetate 
• 7745-40-6 3β-hydroxy-17,17-ethylenedioxo-5-androstene 
• 53-43-0 dehydroepiandrosterone 
• 19449-09-3 3β-acetoxyandrost-4-ene-6,17-dione 

Relevant articles and documents

3β-HYDROXYANDROST-4-EN-6-ONE DERIVATIVES AS AROMATASE INHIBITORS

The 3-formate (II), 3-acetate (III), 3-bromoacetate (IV), 3-propionate (V), 3-methyl ether (VI), and 3-deoxy-derivative (VII) of 3β-hydroxyandrost-4-ene-6,17-dione (I) were synthesized and tested in human placental microsomes for their ability to inhibit aromatase.II, III, and VII of this series were potent inhibitors of aromatase with the IC50's (1.7 and 3.3 μM) of the latter two comparable to that (1.2 μM) of 4-hydroxyandrostenedione.Kinetic studies showed that the three steroids are competitive inhibitors of the enzyme with Ki's of 16.0, 5.5, and 0.61 μM for II, III, and VII.Furthermore, II showed a time-dependent, pseudo-first order rate of inactivation of aromatase with Ki of 20.5 μM and kinact of 1.54 * 10-2 min-1, while III gave a time-dependent, biphasic loss of the enzyme activity.NADPH and oxygen were required for the time-dependent inactivation and the substrate, androstenedione, prevented it.