1840-19-3Relevant articles and documents
-
Cherbuliez et al.
, p. 1031,1032, 1033 (1965)
-
Highly Acidic Conjugate-Base-Stabilized Carboxylic Acids Catalyze Enantioselective oxa-Pictet–Spengler Reactions with Ketals
Zhu, Zhengbo,Odagi, Minami,Zhao, Chenfei,Abboud, Khalil A.,Kirm, Helmi Ulrika,Saame, Jaan,L?kov, M?rt,Leito, Ivo,Seidel, Daniel
supporting information, p. 2028 - 2032 (2019/12/24)
Acyclic ketone-derived oxocarbenium ions are involved as intermediates in numerous reactions that provide valuable products, however, they have thus far eluded efforts aimed at asymmetric catalysis. We report that a readily accessible chiral carboxylic acid catalyst exerts control over asymmetric cyclizations of acyclic ketone-derived trisubstituted oxocarbenium ions, thereby providing access to highly enantioenriched dihydropyran products containing a tetrasubstituted stereogenic center. The high acidity of the carboxylic acid catalyst, which exceeds that of the well-known chiral phosphoric acid catalyst TRIP, is largely derived from stabilization of the carboxylate conjugate base through intramolecular anion-binding to a thiourea site.
DIARYLHYDANTOIN COMPOUNDS AND METHODS OF USE THEREOF
-
Page/Page column 81-82, (2020/06/19)
The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation. The present disclosure provides compounds having hormone receptor antagonist activity. These compounds can be useful in treating cancer, in particular those cancers which can be potentiated by AR and/or GR antagonism.
