369-90-4

Basic information

• Product Name: N-(4-nitrophenyl)-3-(trifluoromethyl)aniline
• Synonyms: N-(4-NITROPHENYL)-3-(TRIFLUOROMETHYL)BENZENAMINE
• CAS NO: 369-90-4
• Molecular Formula: C₁₃H₉F₃N₂O₂
• Molecular Weight: 282.218
• Mol File: 369-90-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 370.5°C at 760 mmHg
• Flash Point: 177.9°C
• Density: 1.405g/cm³
• Vapor Pressure: 1.1E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: N-(4-nitrophenyl)-3-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitrophenyl)-3-(trifluoromethyl)aniline(369-90-4)
• EPA Substance Registry System: N-(4-nitrophenyl)-3-(trifluoromethyl)aniline(369-90-4)

Safety Data

• Hazardous Substances Data: 369-90-4(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 98-95-3 nitrobenzene 
• 100-02-7 4-nitro-phenol 
• 1840-19-3 1-isothiocyanato-3-trifluoromethyl-benzene 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 100-01-6 4-nitro-aniline 
• 401-81-0 m-trifluoromethylphenyl iodide 

Downstream Products

• 1611467-04-9 1-(4-{[3-(trifluoromethyl)phenyl]amino}phenyl)urea 

Relevant articles and documents

Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.

A new Synthesis of 4-Isothiocyanato-4'-nitrodiphenylamine (Amoscanate)

4-Isothiocyanato-4'-nitrodiphenylamine (amoscanate)(1a), an anthelmintic drug now under clinical trials, has been synthesized by the base-catalysed reaction of p-nitrophenol with either p-isothiocyanatophenyl isocyanate or 1,4-phenylenediisothiocyanate.