18672-04-3Relevant articles and documents
PRMT5 INHIBITORS AND USES THEREOF
-
Paragraph 0298-0299, (2019/04/05)
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
A novel organic electron donor derived from N-methylisatin
Sword, Ryan,O'Sullivan, Steven,Murphy, John A.
, p. 314 - 322 (2013/05/08)
We report the reactivity of an electron donor derived from N-methylisatin on reduction by sodium amalgam. Transfer of a clear supernatant solution to iodoarenes affords the products of two-electron reduction. Reductions of sulfones, activated arenesulfonamides, and Weinreb amides are also reported.
One-pot reduction of aryl iodides using 4-DMAP methiodide salt
Garnier, Jean,Murphy, John A.,Zhou, Sheng-Ze,Turner, Andrew T.
scheme or table, p. 2127 - 2131 (2009/05/07)
An efficient one-pot procedure is described for the reduction of aryl iodides to aryl anions using a structurally simple bis-pyridinylidene electron donor, prepared in situ by treating 4-DMAP methiodide salt with base. The results show (i) that pyridinylidene carbenes can be easily used for intermolecular C-C bond formation, (ii) that bis-pyridinylidenes demonstrate superior robustness compared to electron-donor systems based on bis-imidazolylidenes, and (iii) that electron-donor strength is enhanced in the simplified DMAP-based donor. Deuterated analogues of this donor also provide mechanistic information on the source of protons when the aryl anions are quenched in situ. Georg Thieme Verlag Stuttgart.
