18755-56-1

Basic information

• Product Name: 2-(4-Aminophenyl)-2-methylpropan-1-ol
• Synonyms: 2-(4-Aminophenyl)-2-methylpropan-1-ol;Benzeneethanol, 4-aMino-b,b-diMethyl-
• CAS NO: 18755-56-1
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.234
• Mol File: 18755-56-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 301.589°C at 760 mmHg
• Flash Point: 136.196°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-(4-Aminophenyl)-2-methylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Aminophenyl)-2-methylpropan-1-ol(18755-56-1)
• EPA Substance Registry System: 2-(4-Aminophenyl)-2-methylpropan-1-ol(18755-56-1)

Safety Data

• Hazardous Substances Data: 18755-56-1(Hazardous Substances Data)

Usage

General Description

2-(4-Aminophenyl)-2-methylpropan-1-ol, also known as 4-Aminophenyl-2-methyl-2-propanol, is a chemical compound with the molecular formula C10H15NO. It is an aromatic compound with a hydroxyl group attached to a secondary carbon atom. 2-(4-Aminophenyl)-2-methylpropan-1-ol is often used as a reagent in organic synthesis and is a key intermediate in the production of pharmaceuticals and fine chemicals. It is also used as a chiral building block for the synthesis of chiral pharmaceutical compounds. Additionally, it has potential applications in the development of new materials and as a reagent in asymmetric synthesis reactions. The compound is also used as an ingredient in the production of cosmetics and personal care products due to its aromatic properties.

InChI:InChI=1/C10H15NO/c1-10(2,7-12)8-3-5-9(11)6-4-8/h3-6,12H,7,11H2,1-2H3

Upstream product

• 2173-69-5 2-methyl-2-phenyl-propan-1-ol 
• 59115-08-1 methyl 2-methyl-2-(4-nitrophenyl)propanoate 
• 36924-81-9 ethyl 2-(4-aminophenyl)-2-methylpropanoate 
• 83397-45-9 ethyl 2-methyl-2-(4-nitrophenyl)propanoate 
• 18755-52-7 (2-acetoxy-1,1-dimethylethyl)benzene 
• 18755-53-8 2-methyl-2-(4-nitrophenyl)propan-1-ol 

Downstream Products

• 1258234-80-8 2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol 

Relevant articles and documents

Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity

Pyruvate dehydrogenase kinases (PDKs) are promising therapeutic targets that have received increasing attentions in cancer metabolism. In this paper, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones as potent PDKs inhibitors. Structure-activity relationship analysis enabled us to identify a potent compound 6u, which inhibited PDKs with an EC50 value of 0.09 μM, and reduced various cancer cells proliferation with IC50 values ranging from 1.1 to 3.8 μM, while show weak effect against non-cancerous L02 cell (IC50 > 10 μM). In the A375 xenograft model, 6u displayed an obvious antitumor activity at a dose of 5 mg/kg, but with no negative effect to the mice weight. Molecular docking suggested that 6u formed direct hydrogen bond interactions with Ser75 and Gln61 in PDK1, and meanwhile the aniline skeleton in 6u was sandwiched by the conserved hydrophobic residues Phe78 and Phe65, which contribute to the biochemical activity improvement. Moreover, 6u induced A375 cell apoptosis and cell arrest in G1 phase, and inhibited cancer cell migration. In addition, 6u altered glucose metabolic pathway in A375 cell by decreasing lactate formation and increasing ROS production and OCR consumption, which could serve as a potential modulator to reprogram the glycolysis pathway in cancer cell.

IMIDAZOPYRAZINE SYK INHIBITORS

Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suf-fering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of an imidazopyrazine compound effective to reduce signs or symptoms of the disease or dis-order are provided.

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.