187974-79-4

Basic information

• Product Name: Carbamic acid, (1-phenyl-3-butenyl)-, 1,1-dimethylethyl ester
• CAS NO: 187974-79-4
• Molecular Formula: C15H21NO2
• Molecular Weight: 247.337
• Mol File: 187974-79-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (1-phenyl-3-butenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (1-phenyl-3-butenyl)-, 1,1-dimethylethyl ester(187974-79-4)
• EPA Substance Registry System: Carbamic acid, (1-phenyl-3-butenyl)-, 1,1-dimethylethyl ester(187974-79-4)

Safety Data

• Hazardous Substances Data: 187974-79-4(Hazardous Substances Data)

Upstream product

• 150884-50-7 benzaldehyde N-boc imine 
• 2835-06-5 phenylglycin 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2900-27-8 2-(tert-butoxycarbonylamino)-2-phenylacetic acid 
• 356762-89-5 N-(1,1-diphenyl-3-butenyl)amine 
• 591-87-7 Allyl acetate 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 1575-70-8 2-phenyl-pent-4-enoic acid 
• 103-82-2 phenylacetic acid 
• 24850-33-7 allyltributylstanane 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 
• 762-72-1 allyl-trimethyl-silane 
• 107-37-9 allyltrichlorosilane 
• 177896-09-2 tert-butyl benzylidenecarbamate 

Downstream Products

• 374725-03-8 tert-butyl (-formyl-1-phenylethyl)carbamate 
• 865188-31-4 tert-butyl (1S)-4-hydroxy-1-phenylbutylcarbamate 
• 1357361-07-9 6-methylene-4-phenyl-1,3-oxazinan-2-one 
• 118264-04-3 6-phenyl-5,6-dihydro-2,4(1H,3H)-pyridinedione 
• 4383-23-7 1-phenyl-but-3-enylamine 
• 88381-98-0 N-(1-phenyl-3-butenyl)benzylamine 
• 1345893-90-4 tert-butyl 5-oxo-1-phenylhexylcarbamate 
• 56553-09-4 (S)-(-)-5-phenylpyrrolidin-2-one 
• 83649-47-2 (S)-(-)-β-Phenyl-β-alanine hydrochloride 
• 14676-01-8 3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid 

Relevant articles and documents

'meso-Selective' functionalisation of N-benzyl-α-methylbenzylamine derivatives by α-lithiation and alkylation

Lithiation and methylation of amide and carbamate derivatives of α-methylbenzylamine proceeds with high diastereoselectivity in favour of meso bis-α-methylbenzylamine derivatives. Carboxylation of the intermediate organolithium is also diastereoselective, and with N-Boc p-methoxy-α-methylbenzylamine as starting material, oxidative cleavage provides a new asymmetric route to phenylglycine. Other electrophiles give a range of stereochemical outcomes, apparently depending on the stereospecificity of their reactions with a pair of diastereoisomeric organolithiums of low to moderate configurational stability.

Synthesis of Cyclic Guanidines Bearing N-Arylsulfonyl and N-Cyano Protecting Groups via Pd-Catalyzed Alkene Carboamination Reactions

Palladium-catalyzed carboamination reactions of N-allylguanidines bearing cleavable N-cyano or N-arylsulfonyl protecting groups are described. The reactions afford cyclic guanidine products in good yield, and transformations of substrates bearing internal alkenes proceed with high diastereoselectivity. Deuterium labeling studies indicate these transformations proceed via anti-aminopalladation pathways.

Dual Catalytic Decarboxylative Allylations of α-Amino Acids and Their Divergent Mechanisms

The room temperature radical decarboxylative allylation of N-protected α-amino acids and esters has been accomplished via a combination of palladium and photoredox catalysis to provide homoallylic amines. Mechanistic investigations revealed that the stability of the α-amino radical, which is formed by decarboxylation, dictates the predominant reaction pathway between competing mechanisms.