191352-28-0

Basic information

• Product Name: tert-butyl (2-hydroxy-5-nitrophenyl)(methyl)carbamate
• Synonyms: tert-butyl (2-hydroxy-5-nitrophenyl)(methyl)carbamate
• CAS NO: 191352-28-0
• Molecular Weight: 268.269
• Mol File: 191352-28-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl (2-hydroxy-5-nitrophenyl)(methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2-hydroxy-5-nitrophenyl)(methyl)carbamate(191352-28-0)
• EPA Substance Registry System: tert-butyl (2-hydroxy-5-nitrophenyl)(methyl)carbamate(191352-28-0)

Safety Data

• Hazardous Substances Data: 191352-28-0(Hazardous Substances Data)

Upstream product

• 70886-35-0 N-(2-hydroxy-5-nitrophenyl)formamide 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 14703-72-1 2-(methylamino)-4-nitrophenol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 191352-31-5 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-[2-({4-[bis-(2-chloro-ethyl)-amino]-phenoxycarbonyl}-methyl-amino)-4-nitro-phenoxy]-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 191352-27-9 (2S,3S,4S,5R,6S)-6-[2-({4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonyl}-methyl-amino)-4-nitro-phenoxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid 
• 191352-32-6 (2S,3S,4S,5R,6S)-6-[2-({4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonyl}-methyl-amino)-4-nitro-phenoxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 191352-30-4 (2S,3S,4S,5R,6S)-2-(methoxycarbonyl)-6-(2-(methylamino)-4-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 191352-29-1 (2S,3R,4S,5S,6S)-2-(2-((tert-butoxycarbonyl)(methyl)amino)-4-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 

Relevant articles and documents

BENZODICYCLOALKANE DERIVATIVE, PREPARATION METHOD AND USE THEREOF

It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain.

GLUCURONIDE PRODRUGS OF JANUS KINASE INHIBITORS

The invention relates to glucuronide prodrug compounds of Janus kinase (JAK) inhibitors having formula I: where W1, R1 and A1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.

Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): A phenol nitrogen mustard carbamate

A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho-hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed lo