19219-99-9

Basic information

• Product Name: 5-Chloro-2-methylbenzoxazole
• Synonyms: 5-CHLORO-2-METHYLBENZO[D]OXAZOLE;5 CHLORO 2-METHYL BENZOXAZOL;5-CHLORO-2-METHYLBENZOXAZOLE;2-METHYL-5-CHLORO BENZOXAZOLE;2-methyl-5-chlor bezoxazole;7-Chloro-2-Mercato Benzoxazole;Chloro-2-methylbenzoxazole;5-Chloro-2-methylbenzooxazole
• CAS NO: 19219-99-9
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59
• EINECS: 242-888-4
• Product Categories: Isoxazoles, Oxadiazoles, Oxazoles;Oxazole&Isoxazole
• Mol File: 19219-99-9.mol
• Article Data: 24

Chemical Properties

• Melting Point: 55-57 °C(lit.)
• Boiling Point: 218-220 °C(lit.)
• Flash Point: 99.9 °C
• Appearance: Beige crystalline chunks
• Density: 1.2295 (rough estimate)
• Vapor Pressure: 0.0552mmHg at 25°C
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: -0.45±0.10(Predicted)
• CAS DataBase Reference: 5-Chloro-2-methylbenzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-methylbenzoxazole(19219-99-9)
• EPA Substance Registry System: 5-Chloro-2-methylbenzoxazole(19219-99-9)

Safety Data

• Hazard Codes: C,Xi
• Statements: 20/21/22-34-36/37/38-37/38-36
• Safety Statements: 26-27-36/37/39-45-36/39
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• RTECS: DM4790000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 19219-99-9(Hazardous Substances Data)

Usage

Chemical Properties

BEIGE CRYSTALLINE CHUNKS

InChI:InChI=1/C8H6ClNO/c1-5-10-7-4-6(9)2-3-8(7)11-5/h2-4H,1H3

Upstream product

• 26488-93-7 N-(5-chloro-2-hydroxyphenyl)acetamide 
• 55682-66-1 deca-1,3-diyne 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 78-39-7 Triethyl orthoacetate 
• 60386-78-9 4-chloro-2-nitrophenyl acetate 
• 28443-50-7 2-amino-5-chlorophenol 
• 144-55-8 sodium hydrogencarbonate 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 123-54-6 acetylacetone 
• 17749-24-5 3-oxo-dithiobutyric acid methyl ester 
• 1019187-32-6 5'-chloro-2'-hydroxyacetophenone imine 
• 1445-45-0 Trimethyl orthoacetate 
• 106-41-2 4-bromo-phenol 
• 7693-52-9 4-bromo-2-nitrophenol 

Downstream Products

• 13452-16-9 5-chloro-2-methyl-6-nitrobenzoxazole 
• 88787-40-0 4-amino-2-chloro-5-hydroxy-benzenesulfonic acid 
• 1965-76-0 4-[2-(5-chloro-benzooxazol-2-yl)-vinyl]-benzonitrile 
• 61519-90-2 5-chloro-2-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-benzooxazole 
• 61309-91-9 5-chloro-2-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-benzooxazole 
• 61931-68-8 2-methyl-5-phenylbenzo[d]oxazole 
• 178935-04-1 C₁₉H₁₉ClN₂O₄S 
• 182426-61-5 C₂₁H₂₁ClN₂O₅S 
• 903556-80-9 2-methylbenzo[d]oxazole-5-carbonitrile 
• 95-21-6 2-methyl-1,3-benzoxazole 
• 1351403-33-2 5-(sec-butoxy)-2-methylbenzoxazole 
• 1459695-31-8 C₂₀H₂₀ClF₂N₃O₃ 
• 1459695-32-9 C₂₅H₂₂ClF₂N₃O₃ 
• 1459695-33-0 C₂₅H₂₂ClF₂N₃O₄ 

Relevant articles and documents

Use of zeolite catalysts for efficient synthesis of benzoxazoles via Beckmann rearrangement

Substituted benzoxazoles have been synthesized in very good yields starting from o-acylphenol oximes via Beckmann rearrangement using zeolite catalysis.

Multicatalytic Beckmann rearrangement of 2-hydroxylarylketone oxime: Switchable synthesis of benzo[d]oxazoles and N-(2-hydroxylaryl)amides

A switchable synthesis route is developed for benzo[d]oxazole derivatives and (2-hydroxylaryl)benzamide from 2-hydroxylbenzeneketoxime using organomolecules (BOP-Cl, and CNC) and Lewis acid cocatalyzed Beckmann rearrangement (BR) reaction. Further, this reaction is switched using different organocatalysts.

A benzoxazole derivative synthesis method

A synthetic method of benzoxazole derivative belongs to the technical field of organic chemistry synthesis. Raw material of a variety of o-hydroxyphenyl ketimines, an oxidant of iodobenzene diacetate and an additive of alkali are subjected to a simple process comprising one-step oxidation rearrangement, concentration and purification in a solvent at room temperature to obtain a product. This method has the characteristics of certain universality, mild reaction conditions, low production equipment requirement, simple technology, easily obtained raw materials, short reaction time and higher efficiency. Benzoxazole derivative products with high yield and good quality can be prepared by adopting the method of the invention; the method can be widely used in industrial production of benzoxazole derivatives; the products prepared by the method of the invention can be widely used as fluorescent whitening agents, dyeing agents, preservatives, rubber vulcanization accelerators and organic electroluminescent materials, as well as antistatic agent for the plastic films; therefore, the invention has good market application prospects.