1927-06-6Relevant articles and documents
Expanding the structural diversity of hydrophobic ionic liquids: physicochemical properties and toxicity of Gemini ionic liquids
Berdusco, Nicole,Bertz, Colin,Mecozzi, Sandro,Padilla, Marshall S.
, p. 4375 - 4385 (2021)
Ionic liquids (ILs) have been labeled as a promising green alternative to traditional materials; however, many ILs have been discovered to be toxic, especially hydrophobic ILs (HILs). HILs are limited in their structural diversity as most are composed of heteroaromatic cations with long alkyl chains and paired with [BF4], [PF6], or [NTf2] anions. This study aims to diversify HILs by synthesizing two sets of HILs with unique cations and anions. The first set of HILs contain cholinium- and dicholinium-based cations paired with the [NTf2] anion. The [DC-ether] cation is identified as a promising cation and is paired with an array of asymmetric bis(sulfonyl)amide anions to form the second set of HILs. In total, twenty HILs are synthesized. Each HIL is characterized using traditional physicochemical techniques and is evaluted for toxicity usingin vitroandin vivomethods.
Hydrophilic quaternary ammonium type ionic liquids. Systematic study of the relationship among molecular structures, osmotic pressures, and water-solubility
Kawai, Koji,Kaneko, Kotaro,Yonezawa, Tetsu
, p. 7353 - 7356 (2011)
This Letter examines the relationship between the structures of ionic liquids and their water-solubility or osmotic pressure with a number of synthesized quaternary ammonium type ionic liquids and organic salts containing a hydroxyl group as hydrophilic substituted groups on ammonium group cations, and bromide or methylsulfonate as anions. The study found a linear relation between the amount and osmotic pressure of the water-soluble ionic liquids synthesized here, strongly indicating that these water-soluble ionic liquids are perfectly ionized in water like inorganic salts with small diameter ions.
Preparation method and application of near-infrared dye functionalized intelligent super-molecule vesicle
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Paragraph 0046; 0054; 0055, (2018/10/11)
The invention discloses a preparation method and an application of a near-infrared dye functionalized intelligent super-molecule vesicle. According to the preparation method, water solubility column [5] aromatic hydrocarbon (WP5) serves as a main body, a biquaternary ammonium salt functionalized near-infrared dye G based on perylene diimide serves as an objective body, the intelligent super-molecule vesicle is constructed by the aid of acting force of the main body and the objective body between the water solubility column [5] aromatic hydrocarbon and the near-infrared dye, and efficient loading of a drug (hydrophobic anticancer drug adriamycin) can be achieved in the self-assembly process. The near-infrared dye G has excellent near-infrared photo-thermal conversion performance and can serve as a photo-thermal treatment reagent of a tumor. The super-molecule drug load vesicle constructed by the aid of the acting force of the main body and the objective body between the WP5 and the near-infrared dye can stably exist in physiology environments and can rapidly and efficiently release a photo-thermal treatment reagent and a chemotherapy drug in tumor acidic micro-environments, collaborative treatment of photo-thermal treatment/chemotherapy is achieved, the super-molecule drug load vesicle is provided with a good drug delivery system, treatment effect of the tumor is greatly improved, and the super-molecule drug load vesicle has an excellent clinical application prospect.