19333-66-5

Basic information

• Product Name: 2,2-bis(sulfanylmethyl)propane-1,3-diol
• CAS NO: 19333-66-5
• Molecular Formula: C₅H₁₂O₂S₂
• Molecular Weight: 168.2776
• Mol File: 19333-66-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 369.5°C at 760 mmHg
• Flash Point: 177.3°C
• Density: 1.253g/cm³
• Vapor Pressure: 5.78E-07mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 2,2-bis(sulfanylmethyl)propane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-bis(sulfanylmethyl)propane-1,3-diol(19333-66-5)
• EPA Substance Registry System: 2,2-bis(sulfanylmethyl)propane-1,3-diol(19333-66-5)

Safety Data

• Hazardous Substances Data: 19333-66-5(Hazardous Substances Data)

Usage

General Description

2,2-bis(sulfanylmethyl)propane-1,3-diol, also known as tiopronin, is a medication used for the management of cystinuria, a hereditary disease characterized by the formation of cystine stones in the kidneys, ureter, and bladder. 2,2-bis(sulfanylmethyl)propane-1,3-diol works by binding to cystine and forming a soluble complex that can be excreted in the urine, thus reducing the risk of stone formation. Tiopronin is a thiol compound, meaning it contains a sulfur atom, and it is thought to work as a chelating agent, binding to heavy metals in the body and aiding in their removal. It is available as an oral dosage form and is typically used in combination with a high fluid intake to help prevent stone formation in patients with cystinuria.

Upstream product

• 1121-96-6 4,4-Bis-hydroxymethyl-[1,2]dithiolan 
• 132424-79-4 2,2-bis(acetylthiomethyl)-1,3-propandiol 
• 96587-74-5 2,2-dimethyl-5,5-bis-(toluene-4-sulfonyloxymethyl)-[1,3]dioxane 
• 1293392-03-6 5,5-dimethenyl-2,2-dimethyl-1,3-dioxane bis(thiocyanate) 
• 1293392-04-7 1,3-(hydroxymethyl)propane-1,3-diyl bis(thiocyanate) 
• 770-74-1 2,2-dimethyl-5,5-bis(hydroxymethyl)-1,3-dioxane 
• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 
• 7647-01-0 hydrogenchloride 
• 109018-86-2 5,5-bis(acetylthiomethyl)-2,2-dimethyl-1,3-dioxan 

Downstream Products

• 852899-06-0 5,5-bis-hydroxymethyl-2-methyl-2-phenyl-[1,3]dithiane 
• 1360541-83-8 3,9-bis(m-nitrophenyl)-2,4-dioxa-8,10-dithia-spiro[5.5]undecane 
• 1360541-85-0 3,9-bis(m-nitrophenyl)-2,8-dioxa-4,10-dithia-spiro[5.5]undecane 
• 1360541-84-9 3,9-bis(p-nitrophenyl)-2,4-dioxa-8,10-dithia-spiro[5.5]undecane 
• 1121-96-6 4,4-Bis-hydroxymethyl-[1,2]dithiolan 

Relevant articles and documents

OVARIAN CANCER SPECIFICALLY TARGETED BIODEGRADABLE AMPHIPHILIC POLYMER, POLYMER VESICLE PREPARED THEREBY AND USE THEREOF

Provided are an ovarian cancer specifically targeted biodegradable amphiphilic polymer, a polymer vesicle prepared thereby and use thereof. The biodegradable amphiphilic polymer is prepared by a polymer containing dithiocarbonate monomer bonded with targeting molecules. The polymer vesicle prepared with the biodegradable amphiphilic polymer can crosslink spontaneously without adding an extra crosslinker, and the crosslink has a reduction activity and hence can be used in drug controlled-release systems, and contributes to the clinical use and production of nano-drugs.

Disulfide-containing five-membered ring cyclic carbonate functional groups of monomer and its preparation method

Disclosed are a cyclic carbonate monomer containing a double-sulfur five-membered ring functional group, and preparation method thereof. The cyclic carbonate monomer can be simply and efficiently synthesized without protection and deprotection processes. The cyclic carbonate monomer of the present invention can be utilized to obtain polycarbonate having a controllable molecular weight and molecular weight distribution via ring opening polymerization, and has biodegradability and reduction-sensitive reversible crosslinking properties. The present invention can be used in a carrier having controllably released drug, a biological tissue scaffold or a biochip.

The mixed diol-dithiol 2,2-bis-(sulfanylmethyl)propane-1,3-diol: Characterization of key intermediates on a new synthetic pathway

A new synthetic route to 2,2-bis(sulfanylmethyl)propane-1,3-diol, (II), is described starting from the commercially available 2,2-bis(hydroxymethyl) propane-1,3-diol. The structures of two intermediates on this route are described. 5,5-Dimethenyl-2,2-dimethyl-1,3-dioxane bis(thiocyanate) (systematic name: {[5-(cyanosulfanyl)-2,2-dimethyl-1,3-dioxan-5-yl]sulfan-yl}formo-nitrile), C10H14N2O2S2, (X), crystallizes in the space group P21/c with no symmetry relationship between the two thio-cyanate groups. There is a short intra-molecular N...S contact for one thio-cyanate group, while the second group is positioned such that this type of interaction is not possible. 1,3-(Hydroxymethyl)propane-1,3- diyl bis(thiocyanate), C7H10N2O 2S2, (XI), also features a single short N...S contact in the solid state. Hydrogen bonding between two mol-ecules of compound (XI) results in the formation of dimers in the crystal, which are then linked together by a second hydrogen-bond interaction between the dimers. In addition, the structures of two inter-mediates from an unsuccessful alternative synthesis of (II) are reported. 2,2-Bis(chloromethyl)propane-1,3-diol, C5H 10Cl2O2, (VI), crystallized as an inversion twin with a minor twin fraction of 0.43 (6). It forms a zigzag structure as a result of intermolecular hydrogen bonding. The structure of 9,9-di-methyl-2,4,8, 10-tetraoxa-3λ4-thiaspiro-[5.5]undecan-3-one, C 8H14O5S, (VII), shows evidence for a weak S...O contact with a distance of 3.2529 (11) A.