19388-87-5 Usage
Uses
Taurolidine is a derivative of the amino acid Taurine (T007850). Taurolidine exhibits antiendotoxin and antimicrobial activity, and has also been shown to exhibit antitumour activity in vitro and in vivo. Taurolidine is used for the treatment of sepsis and is utilized in hospitals to prevent catheter-related bloodstream infections.
Biological Activity
taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions.taurine, a conditionally-essential amino acid, is not utilized in protein synthesis, but is found free or in simple peptides. taurine has been shown to be essential in mammalian development. in vitro studies have demonstrated that low levels of taurine are associated with various pathological lesions.
in vitro
previous study found that in selected human and murine tumor cell lines, a 3-day exposure to taurolidine could inhibit the growth of all of the cell lines. further mechanistic study showed that in nih-3t3 murine fibroblasts and the pa-1 and skov-3 human ovarian tumor cells, a 48-h exposure to taurolidine had little effect on cell cycle distribution in pa-1 and skov-3 cells but greatly increased the appearance of dna debris, an effect consistent with an induction of apoptosis. in contrast, in nih-3t3 cells, taurolidine exposure did not increase dna debris in the sub-g(0)/g(1) region [1].
in vivo
animal study found that the i.v. administration of 2% taurolidine and 3% taurolidine as well the i.p. application of 2% taurolidine could decrease the development of advanced i.p. tumor lesions. no changes of differential blood count nor relevant animal weight changes resulted. moreover, taurolidine did not impair the liver tissue, kidneys, svc, and leucopoiesis. the intravenous therapy of 2% taurolidine was found to be safe and anti-tumorigenic in advanced local tumor growth in rats [2].
IC 50
9.6-34.2 microm for several cancer cell lines
references
[1] calabresi, p. ,goulette, f.a. and darnowski, j.w. taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent. cancer research 61(18), 6816-6821 (2001).[2] braumann c, stuhldreier b, bobrich e, menenakos c, rogalla s, jacobi ca. high doses of taurolidine inhibit advanced intraperitoneal tumor growth in rats. j surg res. 2005 nov;129(1):129-35.
Check Digit Verification of cas no
The CAS Registry Mumber 19388-87-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,3,8 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 19388-87:
(7*1)+(6*9)+(5*3)+(4*8)+(3*8)+(2*8)+(1*7)=155
155 % 10 = 5
So 19388-87-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
19388-87-5Relevant articles and documents
FUNGICIDAL PENFLUFEN MIXTURES
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, (2014/04/03)
The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.
PROCESS FOR THE PREPARATION OF TAUROLIDINE AND ITS INTERMEDIATES THEREOF
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Page/Page column 4, (2012/06/15)
The present invention relates to a process for the preparation of substantially pure Taurolidine.
3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS
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, (2012/09/11)
The 3-nitroisoxazoles of the formula (I) in which R1 and R2 are each as defined in the description, some of which are known, are highly suitable for use as biocides for protecting industrial materials.
