195257-62-6Relevant articles and documents
Synthesis of cyclic alkenylsiloxanes by semihydrogenation: A stereospecific route to (Z)-alkenyl polyenes
Elbert, Bryony L.,Lim, Diane S. W.,Gudmundsson, Haraldur G.,O'Hanlon, Jack A.,Anderson, Edward A.
, p. 8594 - 8598 (2014/07/21)
Cyclic alkenylsiloxanes were synthesized by semihydrogenation of alkynylsilanes - a reaction previously plagued by poor stereoselectivity. The silanes, which can be synthesized on multigram scale, undergo Hiyama-Denmark coupling to give (Z)-alkenyl polyene motifs found in bioactive natural products. The ring size of the silane is crucial: five-membered cyclic siloxanes also couple under fluoride-free conditions, whilst their six-membered homologues do not, enabling orthogonality within this structural motif.
Rugulactone derivatives act as inhibitors of NF-κB activation and modulates the transcription of NF-κB dependent genes in MDA-MB-231cells
Mohapatra, Debendra K.,Reddy, D. Sai,Janaki Ramaiah,Ghosh, Sowjanya,Pothula, Vikram,Lunavath, Swetha,Thomas, Shine,Pushpa Valli,Bhadra, Manika Pal,Yadav, Jhillu S.
, p. 1389 - 1396 (2014/03/21)
Rugulactone and its analogues were synthesized following Horners-Wadsworth-Emmons and ring-closing metathesis as the key reactions. A library of new rugulactone analogues were designed, synthesized and evaluated for their anticancer activity in breast can
Oxidative heck vinylation for the synthesis of complex dienes and polyenes
Delcamp, Jared H.,Gormisky, Paul E.,White, M. Christina
supporting information, p. 8460 - 8463 (2013/07/19)
We introduce an oxidative Heck reaction for selective complex diene and polyene formation. The reaction proceeds via oxidative Pd(II)/sulfoxide catalysis that retards palladium-hydride isomerizations which previously limited the Heck manifold's capacity f