19641-59-9Relevant articles and documents
A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the xC- transporter
Yang, Hua,Miao, Qing,Johnson, Bruce F.,Rishel, Michael J.,Sossi, Vesna,Dinelle, Katherine,Bénard., Fran?ois,Yapp, Donald T.,Webster, Jack M.,Schaffer, Paul
, p. 5512 - 5515 (2014)
Oxidative stress has been implicated in a variety of conditions, including cancer, heart failure, diabetes, neurodegeneration and other diseases. A potential biomarker for oxidative stress is the cystine/glutamate transporter, system xC-. l-Aminosuberic acid (l-ASu) has been identified as a system xC- substrate. Here we report a facile method for [11C]N-Me labeling of l-ASu, automation of the radiochemical process, and preliminary PET imaging with EL4 tumor bearing mice. The results demonstrate uptake in the tumor above background, warranting further studies on the use of radiolabeled analogs of l-ASu as a PET imaging agent for system xC-.
Inhibitors selective for HDAC6 in enzymes and cells
Gupta, Praveer K.,Reid, Robert C.,Liu, Ligong,Lucke, Andrew J.,Broomfield, Steve A.,Andrews, Melanie R.,Sweet, Matthew J.,Fairlie, David P.
supporting information; experimental part, p. 7067 - 7070 (2011/01/03)
Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.
INHIBITORS OF KYNURENINE AMINOTRANSFERASE AND USES THEREFOR
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Page/Page column 21, (2008/06/13)
Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where R1 is H, NH2 or NHCH3, R2 is H or CH3, n is 0 to 14, and X is -COOH, CH2OH, -PO3H2, -SO2H, or -SO3H; or a pharmacologically acceptable salt.
