19672-59-4

Basic information

• Product Name: 4,4'-Dichlorochalcone
• Synonyms: TRANS-4,4'-DICHLOROCHALCONE;4,4'-DICHLOROCHALCONE;AKOS 94381;1,3-BIS(4-CHLOROPHENYL)PROP-2-EN-1-ONE;4,4''-DICHLOROCHALCONE 98+%;4-Chlorostyryl 4-chlorophenyl ketone;4'-Chloro-β-(4-chlorophenyl)acrylophenone
• CAS NO: 19672-59-4
• Molecular Formula: C₁₅H₁₀Cl₂O
• Molecular Weight: 277.15
• EINECS: -0
• Product Categories: Chalcones
• Mol File: 19672-59-4.mol
• Article Data: 123

Chemical Properties

• Melting Point: 157-159°C
• Boiling Point: 420.1 °C at 760 mmHg
• Flash Point: 177.4 °C
• Appearance: /
• Density: 1.296 g/cm³
• BRN: 2331589
• CAS DataBase Reference: 4,4'-Dichlorochalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Dichlorochalcone(19672-59-4)
• EPA Substance Registry System: 4,4'-Dichlorochalcone(19672-59-4)

Safety Data

• RTECS: UD5572635
• Hazardous Substances Data: 19672-59-4(Hazardous Substances Data)

Usage

General Description

4,4'-Dichlorochalcone is a synthetic compound that belongs to the chalcone family of chemicals. As a dichlorinated derivative of chalcone, it features two chlorine atoms, each attached on both rings of the chalcone structure in the 4,4' positions. Its molecular formula is C15H10Cl2O. Chalcones, including 4,4'-Dichlorochalcone, are known for their wide range of biological activities. This includes their potential in pharmaceutical applications, especially for their anti-inflammatory, antifungal, antitumor, and anti-malarial properties. It’s essential to note that, as with most compounds with biological activity, the exact effects and safety levels of 4,4'-Dichlorochalcone can vary greatly depending on the specific context of its usage, thus requiring extensive research and testing.

Upstream product

• 13677-54-8 1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 67-64-1 acetone 
• 3282-33-5 1-(4-chlorophenyl)-2-diazoethanone 
• 6655-32-9 N'-(4-chlorobenzylidene)-2-nitrobenzenesulfonohydrazide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 99-91-2 para-chloroacetophenone 
• 1513-29-7 (p-chlorophenyl)methanesulfonyl fluoride 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 166823-93-4 (2E)-1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 
• 123-54-6 acetylacetone 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 78572-64-2 1-(4-Chloro-benzoyl)-2-(4-chloro-phenyl)-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 72673-14-4 2,4-Bis(4-chlorophenyl)-6-phenylpyridine 
• 92634-91-8 [(1R,2R,3S)-2-Benzoyl-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 92634-91-8 [(1R,2S,3S)-2-Benzoyl-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 78743-78-9 (4-Chloro-phenyl)-[(1R,2S,3R)-2-(4-chloro-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 78743-78-9 (4-Chloro-phenyl)-[(1R,2S,3S)-2-(4-chloro-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 123033-11-4 [(1R,2R)-2-(4-Chloro-benzoyl)-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 123033-11-4 [(1R,2S,3S)-2-(4-Chloro-benzoyl)-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 74918-93-7 2-(4-Bromo-phenyl)-4,6-bis-(4-chloro-phenyl)-pyridine 
• 77404-28-5 2,4-Bis-(4-chloro-phenyl)-6-(4-methoxy-phenyl)-pyridine 
• 79852-74-7 2,4-Bis-(4-chloro-phenyl)-6-(3-nitro-phenyl)-pyridine 
• 78572-78-8 1-(4-Chloro-benzoyl)-2-(4-chloro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinoline-3-carboxylic acid amide 
• 848089-63-4 diethyl 2-(1,3-bis(4-chlorophenyl)-3-oxopropyl)malonate 
• 1878-66-6 4-chlorophenylacetic Acid 

Relevant articles and documents

Solution phase combinatorial synthesis and screening of mini libraries of arylchalcones for antibacterial activity

The solution-phase combinatorial synthesis of aryl chalcones was studied by synthesizing a 6x4 array mini library. The mini libraries of chalcones were synthesized by condensation of 4-substituted acetophenones and various aryl/heteroaryl carbaldehydes. A

Stereo-controlled deamination of ketoaziridines using Ph3P, I2

Ph3P, I2is an efficient reagent for the stereo-controlled deamination of non-activated aziridines, N-H and N-alkyl aziridines, using. The method works gives the corresponding trans-alkenes from both cis and trans-aziridines. A plausible mechanism is proposed for the ring opening and deamination of keto-aziridines in the presence of Ph3P, I2.

Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process

Herein, a new protocol dealing with the preparation of 1,2-allenyl ketones has been successfully developedviathe reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.