19728-63-3Relevant articles and documents
Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesis
Stigers, Dannon J.,Watts, Zachary I.,Hennessy, James E.,Kim, Hye-Kyung,Martini, Romeo,Taylor, Matthew C.,Ozawa, Kiyoshi,Keillor, Jeffrey W.,Dixon, Nicholas E.,Easton, Christopher J.
, p. 1839 - 1841 (2011)
3-Chloro-Abu and 4-chloro-Nva are biosynthetically incorporated into E. coli peptidyl-Pro cis-trans isomerase B, as substitutes for Val and Leu, respectively. The extent of incorporation is up to ～90%, and substituted protein is catalytically active. By contrast, 4-chloro-Val is not an effective replacement for Ile.
PROCESS AND INTERMEDIATES FOR SYNTHESIS OF PEPTIDE COMPOUNDS
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Paragraph 0176; 0177, (2019/02/13)
Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.
L-threonine-linked dihydroartemisinin-fluoroquinolone conjugates, intermediates thereof, and preparation methods and uses of conjugates and intermediates
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Paragraph 0081-0086, (2019/12/08)
The invention discloses L-threonine-linked dihydroartemisinin-fluoroquinolone conjugates represented by formula I, intermediates represented by formula II, preparation methods of the compounds of formula I and formula II, and uses of the compounds of the formula I in the preparation of drugs for resisting mycobacterium tuberculosis or/and drugs for lowering blood lipids.
