198549-10-9

Basic information

• Product Name: 4-(2-phenylimidazol-1-yl)butanoic acid
• Synonyms: 4-(2-phenylimidazol-1-yl)butanoic acid
• CAS NO: 198549-10-9
• Molecular Weight: 230.266
• Mol File: 198549-10-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-phenylimidazol-1-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-phenylimidazol-1-yl)butanoic acid(198549-10-9)
• EPA Substance Registry System: 4-(2-phenylimidazol-1-yl)butanoic acid(198549-10-9)

Safety Data

• Hazardous Substances Data: 198549-10-9(Hazardous Substances Data)

Upstream product

• 96-48-0 4-butanolide 
• 670-96-2 2-Phenylimidazole 

Downstream Products

• 791856-55-8 5-(4-methoxyphenyl)-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 791856-46-7 3-(3-(2-phenylimidazol-1-yl)propyl)-5-phenyl-1,2,4-triazine 
• 791856-69-4 6-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 791856-65-0 6-phenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 198549-17-6 5,6-diphenyl-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-20-1 5,6-dimethyl-3-(3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine 
• 198549-22-3 6,7-diphenyl-1,2,3,4-tetrahydro-1,5-naphthyridine 
• 198549-14-3 4-(2-phenylimidazol-1-yl)butanoyl hydrazide 
• 791856-44-5 methyl 4-(2-phenylimidazol-1-yl)butanoate 

Relevant articles and documents

Intramolecular inverse-electron-demand Diels-Alder reactions of imidazoles with 1,2,4-triazines: A new route to 1,2,3,4-tetrahydro-1,5-naphthyridines and related heterocycles

The intramolecular inverse-electron-demand Diels-Alder reaction between imidazoles and 1,2,4-triazines linked by a trimethylene tether from the imidazole N1 position to the triazine C3 proceed in excellent yields to produce 1,2,3,4-tetrahydro-1,5-naphthyridines. The reaction proceeds by a cycloaddition with subsequent loss of nitrogen, followed by a presumed stepwise loss of a nitrile. The analogous intramolecular cycloadditions employing a tetramethylene tether also proceeded to give 2,3,4,5-tetrahydro-1H-pyrido[3,2-b]azepines in acceptable yields. The reaction to produce the tetrahydro-1,5-naphthyridines can also be promoted with microwave irradiation.