20035-41-0

Basic information

• Product Name: 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE
• Synonyms: 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE;6-Bromo-2-hydroxy-2-methoxybenzaldehyde;6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE 99+%;2-Hydroxy-3-methoxy-6-bromobenzaldehyde;NSC95682
• CAS NO: 20035-41-0
• Molecular Formula: C₈H₇BrO₃
• Molecular Weight: 231.04
• Product Categories: Chemical Synthesis;Organic Building Blocks;Aldehydes;C8;Carbonyl Compounds;Building Blocks;Carbonyl Compounds
• Mol File: 20035-41-0.mol
• Article Data: 21

Chemical Properties

• Melting Point: 102-105 °C(lit.)
• Boiling Point: 282.1 °C at 760 mmHg
• Flash Point: 124.4 °C
• Appearance: /
• Density: 1.653 g/cm³
• Vapor Pressure: 0.00201mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 7.21±0.15(Predicted)
• CAS DataBase Reference: 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE(20035-41-0)
• EPA Substance Registry System: 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE(20035-41-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 20035-41-0(Hazardous Substances Data)

Usage

Uses

6-Bromo-2-hydroxy-3-methoxybenzaldehyde may be used in the synthesis of:2-benzyloxy-6-bromo-3-methoxybenzaldehydebiphenylsantihypertensive natural products S-(+)-XJP and R-(-)-XJP

General Description

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative. It participates in the synthesis of (±)-norannuradhapurine. Its crystals exhibit monoclinic crystal system and space group P21/n.

InChI:InChI=1/C8H7BrO3/c1-12-7-3-2-6(9)5(4-10)8(7)11/h2-4,11H,1H3

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 92252-86-3 1,1-diacetoxy-1-(2-acetoxy-3-methoxyphenyl)methane 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 159263-87-3 2-acetyloxy-3-methoxy-6-bromobenzaldehyde 
• 7150-01-8 2-acetoxy-3-methoxybenzaldehyde 

Downstream Products

• 64466-51-9 3,6-Dimethoxy-2-hydroxybenzaldehyde 
• 83983-71-5 6-bromo-2,3-dihydroxybenzaldehyde 
• 113250-72-9 2-benzyloxy-6-bromo-3-methoxybenzaldehyde 
• 65162-35-8 4-bromo-3,6-dimethoxysalicylaldehyde 
• 109765-60-8 2,3-dihydroxy-1,4-dimethoxybenzene 
• 108213-73-6 3,6-dimethoxy-1,2-benzoquinone 
• 109765-64-2 3,6-dimethoxy-4-bromo-1,2-benzoquinone 
• 109765-62-0 4-bromo-3,6-dimethoxycatechol 
• 109765-63-1 3,6-dimethoxy-4,5-dichloro-1,2-benzoquinone 
• 109765-61-9 3,6-dimethoxy-4,5-dichlorocatechol 
• 1226513-68-3 isonicotinic acid (6-bromo-2-hydroxy-3-methoxybenzylidene)hydrazide 
• 1226513-69-4 cyanoacetic acid (6-bromo-2-hydroxy-3-methoxybenzylidene)hydrazide 
• 1226513-67-2 4-methyl-[1,2,3]thiadiazole-5-carboxylic acid (6-bromo-2-hydroxy-3-methoxybenzylidene)hydrazide 
• 933040-76-7 6-bromo-2-hydroxy-3-methoxybenzonitrile 

Relevant articles and documents

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The present invention relates to boron containing compounds of Formula (I) [in-line-formulae]X—Y—Z?? Formula (I)[/in-line-formulae] that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

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Fibrauretine synthetic method (by machine translation)

The invention relates to O-vanillin (11) as the starting material, by the acylation reaction generating 2 - acetoxy - 3 - methoxybenzaldehyde (12), by the bromo, hydrolysis reaction to produce the 2 - hydroxy - 6 - bromo - 3 - methoxybenzaldehyde (13), produced by the methylation reaction 6 - bromo - 2, 3 - dimethoxy benzaldehyde (14), produced by the condensation reaction of 2 - (6 - bromo - 2, 3 - dimethoxyphenyl) - 1, 3 - dioxolane (15); and then to 3, 4 - dimethoxy acetic acid (21) as raw materials, generated by the reduction reaction of the 3, 4 - dimethoxy ethanol (22), the acylation reaction generated by 3, 4 - dimethoxy new valeric acid environmentally (23), the acylation reaction is generated by the 2 - ethoxy - 3, 4 - dimethoxy new valeric acid environmentally (24), intermediate (15) and (24) after coupling, cyclized two-step reaction process for preparing the target product fibrauretin. (by machine translation)