2008-59-5

Basic information

• Product Name: Benzene, 1-isocyano-3-nitro- (9CI)
• Synonyms: Benzene, 1-isocyano-3-nitro- (9CI);1-isocyano-3-nitrobenzene;1-isocyano-3-nitro-benzene
• CAS NO: 2008-59-5
• Molecular Formula: C₇H₄N₂O₂
• Molecular Weight: 148.11886
• Product Categories: ISONITRITE
• Mol File: 2008-59-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 97-99 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: Benzene, 1-isocyano-3-nitro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyano-3-nitro- (9CI)(2008-59-5)
• EPA Substance Registry System: Benzene, 1-isocyano-3-nitro- (9CI)(2008-59-5)

Safety Data

• Hazardous Substances Data: 2008-59-5(Hazardous Substances Data)

Usage

Uses

Agricultural chemical.

Hazard

Low toxicity by ingestion.

Safety Profile

Moderately toxic by subcutaneousroute. Low toxicity by ingestion. When heated todecomposition it emits toxic vapors of NOx.

InChI:InChI=1/C7H4N2O2/c1-8-6-3-2-4-7(5-6)9(10)11/h2-5H

Upstream product

• 64-18-6 formic acid 
• 99-09-2 3-nitro-aniline 
• 67-66-3 chloroform 
• 102-38-5 N-(3-nitrophenyl)formamide 

Downstream Products

• 94012-25-6 3-Benzenesulfonyl-4-nitro-1H-indole 
• 94012-20-1 3-Benzenesulfonyl-6-nitro-1H-indole 
• 94012-19-8 1-Benzenesulfonylmethyl-4-isocyano-2-nitro-benzene 
• 94012-42-7 1-Benzenesulfonylmethyl-2-isocyano-4-nitro-benzene 
• 102-38-5 N-(3-nitrophenyl)formamide 
• 118682-73-8 C₇H₅N₂O₃^(1-) 
• 342632-66-0 N-[1-(1H-benzotriazol-1-yl)-4-methyl-2-morpholinopentylidene]-3-nitroaniline 

Relevant articles and documents

Enantioselective Synthesis of Azetidines through [3 + 1]-Cycloaddition of Donor-Acceptor Aziridines with Isocyanides

The enantioselective [3 + 1]-cycloaddition of racemic donor-acceptor (D-A) aziridines with isocyanides was first realized under mild reaction conditions using a chiral N,N′-dioxide/MgIIcomplex as catalyst, providing a facile route to enantioenriched exo-imido azetidines with good to excellent yield (up to 99%) and enantioselectivity (up to 94% ee). An obvious chiral amplification effect was observed in this system, and an explanation was elucidated based on the experimental investigation and X-ray crystal structure of the enantiomerically pure catalyst.

Aerobic radical-cascade cycloaddition of isocyanides, selenium and imidamides: Facile access to 1,2,4-selenadiazoles under metal-free conditions

A novel and facile metal-free method for the green synthesis of 1,2,4-selenadiazol-5-amine derivatives through the aerobic radical-cascade multi-component reactions of isocyanides, selenium powder and imidamides is reported herein. O2 in the air was employed as the green oxidant to achieve the cycloaddition with the generation of H2O as the sole by-product. It also features good functional group compatibility and broad substrate scope. In addition, this method was successfully applied to the functionalization of biologically active molecules.

Synthesis of isonitriles from N-substituted formamides using triphenylphosphine and iodine

Treatment of N-substituted formamides with the reagent combination of triphenylphosphine and molecular iodine, in the presence of a tertiary amine, quickly produces the corresponding isocyanides in high yields under ambient conditions. The process employs readily available and low-cost reagents, a convenient synthetic procedure, and mild reaction conditions for the synthesis of various alkyl and aryl isocyanides.