2040-88-2

Basic information

• Product Name: 2-bromo-6-chloro-phenol
• Synonyms: 2-bromo-6-chloro-phenol;Phenol, 2-broMo-6-chloro-
• CAS NO: 2040-88-2
• Molecular Formula: C₆H₄BrClO
• Molecular Weight: 207.46
• Mol File: 2040-88-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 50-52 °C
• Boiling Point: 204.6 °C at 760 mmHg
• Flash Point: 77.5 °C
• Appearance: /
• Density: 1.788 g/cm³
• Vapor Pressure: 0.183mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 6.96±0.10(Predicted)
• CAS DataBase Reference: 2-bromo-6-chloro-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-6-chloro-phenol(2040-88-2)
• EPA Substance Registry System: 2-bromo-6-chloro-phenol(2040-88-2)

Safety Data

• Hazardous Substances Data: 2040-88-2(Hazardous Substances Data)

Usage

General Description

2-bromo-6-chloro-phenol is a chemical compound consisting of a six-carbon phenol ring with bromine and chlorine substituents. It is a white to light brown crystalline solid with a faint phenolic odor, and it is sparingly soluble in water. The compound is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also used as a disinfectant and fungicide. 2-bromo-6-chloro-phenol is classified as a hazardous substance and should be handled with care due to its toxic and irritant properties.

InChI:InChI=1/C6H4BrClO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H

Upstream product

• 104892-01-5 2-Bromo-6-chloro-phenol; compound with dimethyl-amine 
• 95-57-8 2-monochlorophenol 
• 95-56-7 2-hydroxybromobenzene 
• 108-95-2 phenol 
• 1534364-16-3 2-bromo-6-chlorophenyl dimethylcarbamate 
• 7305-04-6 o-bromophenyl N,N-dimethylcarbamate 
• 6969-90-0 phenyl N,N-dimethylcarbamate 
• 1360939-08-7 2-deuterio-phenyl dimethylcarbamate 
• 7305-01-3 o-chlorophenyl dimethylcarbamate 
• 23951-01-1 <2-D>-phenol 
• 4526-56-1 2,4-dibromo-6-chlorophenol 

Downstream Products

• 1043912-15-7 2-bromo-6-chloro-1-trifluoromethanesulfonyloxybenzene 
• 1449472-59-6 2-chloro-6-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1010390-50-7 C₈H₈BrClO 
• 21244-80-4 2-Brom-6-chlor-phenyl-oxyacetonitril 

Relevant articles and documents

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

Room-temperature Pd-catalyzed C-H chlorination by weak coordination: One-pot synthesis of 2-chlorophenols with excellent regioselectivity

A room-temperature Pd(ii)-catalyzed regioselective chlorination reaction has been developed for a facile one-pot synthesis of a broad range of 2-chlorophenols. The reaction demonstrates an excellent regioselectivity and reactivity for C-H chlorination. This reaction represents one of the rare examples of mild C-H functionalization at ambient temperature.