20428-71-1

Basic information

• Product Name: 3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide
• Synonyms: 3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide
• CAS NO: 20428-71-1
• Molecular Weight: 207.272
• Mol File: 20428-71-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide(20428-71-1)
• EPA Substance Registry System: 3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide(20428-71-1)

Safety Data

• Hazardous Substances Data: 20428-71-1(Hazardous Substances Data)

Upstream product

• 758-96-3 N,N-dimethyl-propanamide 
• 100-52-7 benzaldehyde 
• 108471-82-5 N,N,2-trimethyl-3-oxo-3-phenylpropanamide 
• 72590-45-5 2-formyl-N,N-dimethylpropanamide 
• 3530-39-0 phenylaluminium dichloride 
• 21306-27-4 Phenyltitantrichlorid 
• 2680-03-7 N,N-Dimethylacrylamide 

Downstream Products

• 108471-82-5 N,N,2-trimethyl-3-oxo-3-phenylpropanamide 
• 20428-71-1 (2RS,3RS)-3-hydroxy-N,N,2-trimethyl-3-phenylpropanamide 
• 26919-89-1 (1RS,2SR)-3-(dimethylamino)-2-methyl-1-phenyl-1-propanol 
• 26919-89-1 (1R,2R)-3-Dimethylamino-2-methyl-1-phenyl-propan-1-ol 

Relevant articles and documents

Highly diastereoselective synthesis of β-hydroxy amides from β-keto amides

β-Hydroxy amides with stereodefined geometry represent an important unit present in various natural products. The diastereoselective preparation of amides carrying a secondary or tertiary alcohol in β-position is described here.

One-pot highly stereoselective reduction of β-keto amides to syn-γ-aminols

In the presence of titanium tetrachloride, the borane/tetrahydrofuran complex can reduce 2-methyl-3-oxoamides into the corresponding syn-aminols in good yields and high diastereoselectivity. The use of borane/dimethyl sulfide instead of BH3/THF

Stereoselective Addition of Organoaluminium or Organomanganese Reagents to α-Formyl Amides or α-Methyl-Substituted β-Keto Amides

Treatment of α-formyl amides with RAlCl2 or PhAlCl2 provided threo-α-alkyl-substituted β-hydroxy amides under high stereocontrol.The method was successfully applied to the selective addition of alkyl group to α-methyl-substituted β-keto amides or esters.Treatment of α-methyl-β-keto amides or α-methyl-β-keto esters with trialkylaluminium or alkylmanganese halide afforded the corresponding erythro (or threo) α-methyl-substituted β-hydroxy amides or α-methyl-substituted β-hydroxy esters with high stereoselectivity.