205-43-6Relevant articles and documents
Synthesis method of benzo[b] naphtho [2,3-d] thiophene
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Paragraph 0056-0058; 0071-0074; 0085-0087; 0098-0099; .., (2022/03/27)
The present invention discloses a method for synthesizing benzo [b] naphthio [2,3-d] thiophene, comprising the following steps: 2-aminobenzo [d] thiazole as a raw material, under the action of alkali and haloalkanes, to prepare 2- (methylthio) aniline; using 2- (methylthio) aniline to prepare (2-iophenyl) (methyl) thiane preparation of 1-iodo-2-(methylsulfonyl) benzene; using 1-iodo-2-(methylsulfonyl) benzene; using 1-iodo-2-(methylsulfonyl) Benzene and compound S5 were prepared to obtain 1-(2-(methyl sulfoxide phenyl)) naphthalene, and 1-(2-(methyl sulfoxidephenyl)) naphthalene was used to obtain benzo[b]naphthalene [2,3-d]thiophene. The present invention employs a green route to obtain high yield, high quality benzo [b] naphthalene [2,3-d] thiophene.
Br?nsted Acid-Catalyzed Carbonyl-Olefin Metathesis: Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst
Chen, Yi,Jin, Yuan,Lin, Zhihua,Liu, Di,Shu, Mao,Tan, Jingyao,Tian, Lingfeng,Wang, Rui,Xu, Li,Zhang, Xiaoke
, (2022/01/03)
Compared with the impressive achievements of catalytic carbonyl-olefin metathesis (CCOM) mediated by Lewis acid catalysts, exploration of the CCOM through Br?nsted acid-catalyzed approaches remains quite challenging. Herein, we disclose a synthetic protocol for the construction of a valuable polycycle scaffold through the CCOM with the inexpensive, nontoxic phosphomolybdic acid as a catalyst. The current annulations could realize carbonyl-olefin, carbonyl-alcohol, and acetal-alcohol in situ CCOM reactions and feature mild reaction conditions, simple manipulation, and scalability, making this strategy a promising alternative to the Lewis acid-catalyzed COM reaction.
Helicene synthesis by Br?nsted acid-catalyzed cycloaromatization in HFIP [(CF3)2CHOH]
Fujita, Takeshi,Shoji, Noriaki,Yoshikawa, Nao,Ichikawa, Junji
, p. 396 - 403 (2021/03/20)
A facile synthesis of carbo- and heterohelicenes was achieved via tandem cycloaromatization of bisacetal precursors, which were readily prepared through C-C bond formation by Suzuki-Miyaura coupling. This cyclization was efficiently realized by a catalytic amount of trifluoromethanesulfonic acid (TfOH) in a cation-stabilizing solvent, 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP), which readily allowed gram-scale syntheses of higher-order helicenes, double helical helicenes, and heterohelicenes.