206055-82-5

Basic information

• Product Name: DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE
• Synonyms: DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE;DMT-LOCMEC(BZ)AMIDITE 0.25G ABI SINGLE;DMT-locMeC(bz)Amidite 1g, ABI, Single;DMT-LOCMEC(BZ)AMIDITE 1.0G 89 SINGLE;N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-5-methylcytidine
• CAS NO: 206055-82-5
• Molecular Formula: C48H54N5O9P
• Molecular Weight: 875.94
• Mol File: 206055-82-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• PKA: 8.59±0.40(Predicted)
• CAS DataBase Reference: DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE(CAS DataBase Reference)
• NIST Chemistry Reference: DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE(206055-82-5)
• EPA Substance Registry System: DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE(206055-82-5)

Safety Data

• Hazardous Substances Data: 206055-82-5(Hazardous Substances Data)

Usage

Description

DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE is a locked-nucleic acid (LNA) oligonucleotide that plays a crucial role in oligonucleotide synthesis. It is characterized by the presence of a DMT (dimethoxytrityl) group, which is a protecting group used in the synthesis process. The LNA oligonucleotide is known for its high stability and affinity for complementary RNA, making it a valuable tool in the development of therapeutics and diagnostic tools.

Uses

Used in Pharmaceutical Industry:
DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE is used as a building block in the synthesis of LNA oligonucleotides for the development of pharmaceuticals targeting specific mRNA sequences. Its high stability and affinity for RNA make it an ideal candidate for the creation of antisense drugs, which can modulate gene expression and treat various diseases.
Used in Diagnostic Industry:
In the diagnostic industry, DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE is used as a component in the development of LNA-based probes for molecular diagnostics. These probes can be employed in techniques such as real-time PCR, in situ hybridization, and microarrays to detect and quantify specific nucleic acid sequences, enabling accurate diagnosis of diseases and conditions.
Used in Research and Development:
DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE is also used in research and development settings to study the interactions between LNA oligonucleotides and their target RNA sequences. This can provide valuable insights into the mechanisms of gene regulation and the development of novel therapeutic strategies.
Overall, DMT-LOCMEC(BZ)AMIDITE 0.25G 89 SINGLE is a versatile and essential component in the synthesis of LNA oligonucleotides, with applications spanning across the pharmaceutical, diagnostic, and research industries. Its unique properties make it a promising tool for the development of innovative therapies and diagnostic methods.

Upstream product

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• 230631-18-2 1-(3-O-Benzyl-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)thymine 
• 601512-74-7 1-[2-O-acetyl-3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α-L-threo-pentofuranosyl]thymine 
• 601512-82-7 1-[3-O-benzyl-5-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α-L-threo-pentofuranosyl]thymine 
• 410076-93-6 3-O-benzyl-1,2-di-O-acetyl-5-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α,β-L-threo-pentofuranose 
• 410076-92-5 3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-1,2-O-isopropylidene-β-L-threo-pentofuranose 
• 296253-28-6 1-[3-O-benzyl-2,5-di-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α-L-threo-pentofuranosyl]thymine 
• 296253-29-7 (1R,3R,4S,7R)-1-(hydroxymethyl)-7-benzyloxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 284497-21-8 (1S,3R,4S,7R)-7-hydroxy-1-(hydroxymethyl)-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 245366-58-9 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 65-71-4 thymin 
• 902452-84-0 1-[3-O-acetyl-5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-α-L-ribofuranosyl]-5-methyl-4-(1,2,4-triazol-1-yl)-2-oxypyrimidine 
• 902452-82-8 1-[3-O-acetyl-5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-α-L-ribofuranosyl]thymine 
• 902452-67-9 1-(3-O-benzyl-5-O-methanesulfonyl-2-O,4-C-methylene-α-L-ribofuranosyl)thymine 

Relevant articles and documents

NOVEL PROCESS FOR MAKING ALLOFURANOSE FROM GLUCOFURANOSE

The present invention relates to the manufacture of allofuranose from glucofuranose as defined in the description and in the claim. Allofuranos is an intermediate in the manufacture of oligonucleotides which can be used as a medicament.

Method for preparation of LNA phosphoramidites

The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N′,N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g. 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphoramidite and 4,5-dicyanoimidazole. The method is faster and more cost efficient that previously known methods.

α-LNA (locked nucleic acid with α-D-configuration): Synthesis and selective parallel recognition of RNA

α-LNA is presented as a stereoisomer of LNA (locked nucleic acid) with α-D-configuration. Three different approaches towards the thymine α-LNA monomer as well as the 5-methylcytosine α-LNA monomer are presented. Different α-LNA sequences have been synthesised and their hybridisation with complementary DNA and RNA has been evaluated by means of thermal stability experiments and circular dichroism spectroscopy. In a mixed pyrimidine sequence, α-LNA displays unprecedented parallel-stranded and selective RNA binding. Furthermore, a remarkable selectivity for hybridisation with RNA over DNA is indicated.