206190-28-5

Basic information

• Product Name: 4(3H)-Quinazolinone, 6-phenyl-
• Synonyms: 4(3H)-Quinazolinone, 6-phenyl-;6-Phenyl-4(1H)-quinazolinone;6-Phenylquinazolin-4(3H)-one
• CAS NO: 206190-28-5
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222
• Mol File: 206190-28-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.24
• CAS DataBase Reference: 4(3H)-Quinazolinone, 6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 6-phenyl-(206190-28-5)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 6-phenyl-(206190-28-5)

Safety Data

• Hazardous Substances Data: 206190-28-5(Hazardous Substances Data)

Usage

General Description

4(3H)-Quinazolinone, 6-phenyl- is a chemical compound with the molecular formula C15H11N3O. It is a quinazolinone derivative which is commonly used as a building block in medicinal chemistry and drug discovery. 4(3H)-Quinazolinone, 6-phenyl- holds promising potential in the development of new pharmaceuticals, particularly in the field of cancer research and treatment. It exhibits various biological activities, including anti-tumor, anti-inflammatory, and anti-microbial properties, making it a valuable target for drug development. Additionally, its unique structural properties make it a versatile intermediate for the synthesis of diverse bioactive compounds. Overall, 4(3H)-Quinazolinone, 6-phenyl- is an important chemical with potential therapeutic applications.

Upstream product

• 4445-40-3 2-Amino-5-phenyl-benzoic acid 
• 77287-34-4 formamide 
• 16064-08-7 6-iodoquinazolin-4(3H)-one 
• 497-19-8 sodium carbonate 
• 98-80-6 phenylboronic acid 
• 16313-66-9 5-bromoanthranilamide 
• 890402-92-3 4-amino-[1,1‘-biphenyl]-3-carboxamide 
• 67-56-1 methanol 
• 28144-70-9 anthranilic acid amide 
• 32084-59-6 6-bromoquinazolin-4(3H)-one 

Downstream Products

• 127662-21-9 3-phenyl-1,2,3,4-tetrahydroquinazoline 

Relevant articles and documents

Visible-Light Photosynthesis of CHF2/CClF2/CBrF2-Substituted Ring-fused Quinazolinones in Dimethyl Carbonate

With eco-friendly and sustainable CO2-derived dimethyl carbonate as the sole solvent, the visible-light-induced cascade radical reactions have been established as a green and efficient tool for constructing various CHF2/CClF2/CBrF2-substituted ring-fused quinazolinones.

Structure-metabolism relationships in human-AOX: Chemical insights from a large database of aza-aromatic and amide compounds

Aldehyde oxidase (AOX) is a metabolic enzyme catalyzing the oxidation of aldehyde and aza-aromatic compounds and the hydrolysis of amides, moieties frequently shared by the majority of drugs. Despite its key role in human metabolism, to date only fragmentary information about the chemical features responsible for AOX susceptibility are reported and only "very local" structure-metabolism relationships based on a small number of similar compounds have been developed. This study reports a more comprehensive coverage of the chemical space of structures with a high risk of AOX phase I metabolism in humans. More than 270 compounds were studied to identify the site of metabolism and themetabolite(s). Both electronic [supported by density functional theory (DFT) calculations] and exposure effects were considered when rationalizing the structure-metabolism relationship.

4-aminoquinazolone derivatives

This invention relates to certain 4-aminoquinazoline derivatives of the formula and their pharmaceutically acceptable salts wherein R1, Q1, m, n, and Z are defined as in the specification. The compounds of formula I and pharmaceutically acceptable salts are useful for the treatment of hyperproliferative disorders and conditions in mammals.