20737-42-2

Basic information

• Product Name: 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
• Synonyms: 3-HYDROXY-PIPERAZINE-2-CARBOXYLIC ACID;3-HYDROXYPYRAZINE-2-CARBOXYLIC ACID;2-HYDROXY-3-PYRAZINECARBOXYLIC ACID;3-Hydroxy-2-pyrazinecarboxylic acid;3-hydroxy-2-pyrazinecarboxylic acid(SALTDATA: FREE);3-Hydroxypyrazinecarboxylic acid;3-Hydroxypyrazine-2-carbo...;2-Carboxy-3-hydroxypyrazine
• CAS NO: 20737-42-2
• Molecular Formula: C₅H₄N₂O₃
• Molecular Weight: 140.1
• Product Categories: pharmacetical;Piperazine series;Pyrazine
• Mol File: 20737-42-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 218-220 °C
• Boiling Point: 608.49 °C at 760 mmHg
• Flash Point: 321.804 °C
• Appearance: /
• Density: 1.613 g/cm³
• Vapor Pressure: 1.17E-15mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: 2-8°C
• PKA: 12.72±0.20(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID(20737-42-2)
• EPA Substance Registry System: 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID(20737-42-2)

Safety Data

• Hazardous Substances Data: 20737-42-2(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-3-PYRAZINECARBOXYLIC ACID, also known as 2-Hydroxypyrazine-3-carboxylic acid, is a chemical compound with the molecular formula C5H4N2O3. It is a derivative of pyrazine and is commonly used as a flavor enhancer in food and beverage products. 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID is known for its nutty, roasted, and earthy flavor profile and is often used in savory dishes such as soups, sauces, and meat products. It is also used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its unique chemical properties. Additionally, 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID has been studied for its potential health benefits, including antioxidant and anti-inflammatory properties.

InChI:InChI=1/C5H4N2O3/c8-4-3(5(9)10)6-1-2-7-4/h1-2H,(H,7,8)(H,9,10)

Upstream product

• 487-21-8 Lumazine 
• 5424-01-1 3-aminopyrazinoic acid 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 55321-99-8 3-oxo-3,4-dihydropyrazine-2-carboxamide 

Downstream Products

• 27825-20-3 methyl 3-oxo-3,4-dihydropyrazine-2-carboxylate 
• 6270-63-9 pyrazin-2(1H)-one 
• 90361-99-2 2-chloro-3-pyrazinylcarbonyl chloride 
• 63012-78-2 1,2-Dihydro-5H-thiazolo<3,2-a>pteridin-5-on 
• 27398-39-6 3-chloropyrazine-2-carboxylic acid 
• 1204400-34-9 4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydropyrazine-2-carboxyIic acid 
• 1204400-32-7 methyl 4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydiropyrazine-2-carboxylate 
• 55321-99-8 3-oxo-3,4-dihydropyrazine-2-carboxamide 
• 188622-55-1 3-(5-Chloro-2-fluoro-benzyl)-pyrazine-2-carboxylic acid methyl ester 
• 188622-62-0 2-(2-fluoro-5-chlorobenzyl)pyrazine-3-carboxylic acid 
• 27825-20-3 3-hydroxypyrazine-2-carboxylic acid methyl ester 

Relevant articles and documents

Derivatives of pyrazinecarboxylic acid: 1H, 13C and 15N NMR spectroscopic investigations

NMR spectroscopic studies are undertaken with derivatives of 2-pyrazinecarboxylic acid. Complete and unambiguous assignment of chemical shifts (1H, 13C, 15N) and coupling constants (1H,1H; 13C,1H; 15N,1H) is achieved by combined application of various 1D and 2D NMR spectroscopic techniques. Unequivocal mapping of13C,1H spin coupling constants is accomplished by 2D (S,J) long-range INEPT spectra with selective excitation. Phenomena such as the tautomerism of 3-hydroxy-2-pyrazinecarboxylic acid are discussed.

USE OF MORPHINAN DERIVATIVES FOR TREATMENT OF OPIOID RECEPTOR AGONIST-RELATED DISEASES

The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid δ receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid δ receptor-related diseases (for example, headache) can be treated or prevented.

Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: synthesis and antimycobacterial evaluation

A series of alkylamino derivatives of N-benzylpyrazine-2-carboxamide was designed, synthesized and assayed in vitro for their antimycobacterial, antibacterial, antifungal as well as antiviral activities. Final structures were prepared from 6-chloro (1), 5-chloro (2) or 3-chloro (3) derivatives of N-benzylpyrazine-2-carboxamide by nucleophilic substitution of chlorine with n-alkylamines in the range from butylamine to octylamine (labelled a-e). Series 1a-e and 2a-e exerted higher activity against Mycobacterium tuberculosis H37Rv compared to the corresponding pattern compounds and the reference compound pyrazinamide. The most active derivatives reached an activity MIC = 4.6-10 μM (M. tbc H37Rv). More importantly, activity was also observed against other tested mycobacterial strains (including drug-resistant strains). Substitution of 3-chlorine was disadvantageous and led to completely inactive compounds 3a-e. Some compounds showed activity against Gram-positive bacterial strains (including MRSA) or influenza virus, but no antifungal activity was observed.