20743-49-1Relevant articles and documents
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Isoda et al.
, p. 2176,2180 (1973)
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Alkylation of 5-Substituted 1 H-Tetrazoles via the Diazotization of Aliphatic Amines
Lebel, Hélène,Reynard, Guillaume
, p. 12452 - 12459 (2021/09/07)
A new alkylation reaction of monosubstituted tetrazoles via the diazotization of aliphatic amines is reported. This method enables preferential formation of 2,5-disubstituted tetrazoles. A one-pot 1,3-dipolar cycloaddition/diazotization sequence starting from widely available nitriles is also described. Azide residues are quenched in the second step with the nitrite reagent, thus limiting the intrinsic risk associated with trimethylsilyl azide. The reaction conditions were compatible with several functional groups, including thiocyanates, which afford preferentially disubstituted 2-alkyl-5-(substituted-thio)tetrazoles.
Ruthenium-Catalyzed meta-Selective C?H Nitration of Biologically Important Aryltetrazoles
Chen, Jian,Huang, Tianle,Gong, Xinrui,Yu, Zhu-Jun,Shi, Yuesen,Yan, Yu-Hang,Zheng, Yang,Liu, Xuexin,Li, Guo-Bo,Wu, Yong
, p. 2984 - 2989 (2020/06/08)
The first example of tetrazole-directed meta-selective C?H nitration is described. This transformation provided a straightforward approach for the synthesis of biologically important m-nitroaryltetrazoles in moderate to excellent yields with good functional group compatibility. In addition, new metallo-β-lactamase inhibitors were obtained by further transformation of the synthesized m-nitroaryltetrazoles. (Figure presented.).
ACLY INHIBITORS AND USES THEREOF
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Paragraph 00409, (2020/06/01)
The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.