208450-84-4Relevant articles and documents
Water-soluble self-assembled butadiyne-bridged bisporphyrin: A potential two-photon-absorbing photosensitizer for photodynamic therapy
Dy, Joanne T.,Ogawa, Kazuya,Satake, Akiharu,Ishizumi, Atsushi,Kobuke, Yoshiaki
, p. 3491 - 3500 (2007)
We have synthesized a novel, two-photon-absorbing photosensitizer for two-photon-absorption photodynamic therapy (2PA-PDT). The molecule is a butadiyne-bridged porphyrin dimer terminated with two water-soluble porphyrin monomers connected through Zn-imida
Biaryl and atropisomeric biaryl aldehyde synthesis by one-step, metal-free benzannulation of aryl enals and propiolates
Hu, Deqing,Wan, Jie-Ping,Yang, Lu
supporting information, p. 6773 - 6777 (2020/11/09)
A new method involving the benzannulation of aromatic enals and two alkyl propiolate molecules has been developed as a powerful route to biaryl aldehydes simply via the promotion of dimethyl amine. The benzannulation process in the absence of an oxidant additive tolerates successfully the formyl group in the enal component, leading to a straightforward one-step synthesis of biaryl and atropisomeric aldehydes. An enamine activation based on the aza-Michael addition of dimethyl amine to the propiolate and the amine elimination-based generation of cyclohexadiene intermediate constitute the major factors enabling the titled reactions. This journal is
Anionic hexadeca-carboxylate tetrapyrazinoporphyrazine: Synthesis and in vitro photodynamic studies of a water-soluble, non-aggregating photosensitizer
MacHacek, Miloslav,Kollár, Jan,Miletin, Miroslav,Ku?era, Radim,Kubát, Pavel,Simunek, Tomas,Novakova, Veronika,Zimcik, Petr
, p. 10064 - 10077 (2016/02/05)
A sodium salt of zinc tetrapyrazinoporphyrazine bearing eight 3,5-dicarboxylatophenyl substituents (1) was synthesized. The presence of sixteen negative charges in a rigid arrangement on the periphery of the macrocycle inhibited its aggregation in water or buffers at pH > 5.8. Strong aggregation was, however, observed in buffers at pH 50 = 5.7 ± 1.1 μM) was found to be influenced by both pH and interactions with serum proteins. This was demonstrated with a detailed in vitro study based on the inhibition of vacuolar H+-ATPase using bafilomycin A1, which increased the intracellular fluorescence of 1. Compound 1 also formed interactions with serum proteins that partially quenched its excited states; however, they also protected the compound from self-aggregation at low pH.
