21331-80-6

Basic information

• Product Name: (2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE
• Synonyms: (2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE;(2-Dimethylaminoethyl)triphenylphosphonium bromide,97%
• CAS NO: 21331-80-6
• Molecular Formula: Br*C₂₂H₂₅NP
• Molecular Weight: 414.32
• EINECS: 244-335-2
• Product Categories: Phosphonium Compounds;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction;Wittig Reaction
• Mol File: 21331-80-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 195-200 °C (dec.)(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: Almost white to yellow-brown/Powder
• Density: g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Hygroscopic
• BRN: 4072092
• CAS DataBase Reference: (2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE(21331-80-6)
• EPA Substance Registry System: (2-DIMETHYLAMINOETHYL)TRIPHENYLPHOSPHONIUM BROMIDE(21331-80-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 21331-80-6(Hazardous Substances Data)

Usage

Chemical Properties

almost white to yellow-brown powder

Uses

[2-(Dimethylamino)ethyl]triphenylphosphonium Bromide, can be used as a polymerizable cationic surfactant for the intercalation of montmorillonite (MMT), used in the synthesis of polystyrene-clay nanocomposite materials. It can also be used for the synthesis of some analogs of morphine 6-glucuronide through Wittig reactions.

InChI:InChI=1/C22H25NP.BrH/c1-23(2)18-19-24(20-12-6-3-7-13-20,21-14-8-4-9-15-21)22-16-10-5-11-17-22;/h3-17H,18-19H2,1-2H3;1H/q+1;/p-1

Upstream product

• 55894-16-1 (2-methoxyethyl)triphenylphosphonium bromide 
• 124-40-3 dimethyl amine 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 603-35-0 triphenylphosphine 

Downstream Products

• 139938-17-3 Dimethyl-((Z)-3-phenyl-3-pyridazin-4-yl-allyl)-amine 
• 139938-16-2 Dimethyl-((E)-3-phenyl-3-pyridazin-4-yl-allyl)-amine 
• 681171-41-5 {6-[4-(3-dimethylamino-propenyl)-5-ethyl-2-methoxy-phenyl]-pyridin-2-yl}-carbamic acid tert-butyl ester 
• 886042-21-3 (2Z)-2-[14-cyclohexyl-11-(methoxycarbonyl)-6H-indolo[1,2-e][1,5]benzoxazocin-7(8H)-ylidene]-N,N-dimethylethanaminium trifluoroacetate 
• 886042-19-9 (2Z)-2-[14-cyclohexyl-11-(methoxycarbonyl)-6H-indolo[1,2-e][1,5]benzoxazocin-7(8H)-ylidene]-N,N-dimethylethanaminiumtrifluoroacetate 
• 423166-75-0 Acetic acid 4-[(E)-1-(4'-bromo-biphenyl-4-yl)-3-dimethylamino-propenyl]-phenyl ester 

Relevant articles and documents

Heterocyclic compound serving as SOS1 inhibitor

The invention provides a compound serving as an SOS1 inhibitor, and particularly provides a compound with a structure as shown in a formula (I), or an optical isomer, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative, a hydrate and a solvate of the compound. The compound can be used for treating or preventing diseases or symptoms related to the activity or expression quantity of SOS1.

Synthesis of 2-(N-disubstituted amino)ethyltriphenylphosphonium bromides

2-(N-Disubstituted amino)ethyltriphenylphosphonium bromides are prepared in quantitative yields with high purity by reacting secondary amines with 2-methoxyethyltriphenylphosphonium bromide under aqueous conditions. The differential reactivity of this reagent offers advantages for the preparation of aminoethyltriphenylphosphonium bromides possessing nucleophiles such as hydroxy groups.