2144-37-8

Basic information

• Product Name: METHYL 5-(CHLOROMETHYL)-2-FUROATE
• Synonyms: 5-CHLOROMETHYL-FURAN-2-CARBOXYLIC ACID METHYL ESTER;AKOS BC-1864;AKOS B006673;AKOS BBS-00001414;METHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE;METHYL 5-(CHLOROMETHYL)-2-FURATE;METHYL 5-(CHLOROMETHYL)-2-FUROATE;ART-CHEM-BB B006673
• CAS NO: 2144-37-8
• Molecular Formula: C₇H₇ClO₃
• Molecular Weight: 174.58
• EINECS: 218-405-8
• Product Categories: API intermediates;Building Blocks;C4 to C7;C4 to C8;Chemical Synthesis;Furans;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 2144-37-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 32-36 °C(lit.)
• Boiling Point: 102 °C (15 mmHg)
• Flash Point: >230 °F
• Appearance: White to yellow/Low Melting Crystalline Solid or Oily Liquid
• Density: 1.266 g/cm³
• Vapor Pressure: 0.00781mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Refrigerator (+4°C)
• Solubility: Chloroform, Methanol (Slightly)
• CAS DataBase Reference: METHYL 5-(CHLOROMETHYL)-2-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-(CHLOROMETHYL)-2-FUROATE(2144-37-8)
• EPA Substance Registry System: METHYL 5-(CHLOROMETHYL)-2-FUROATE(2144-37-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37-45
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2144-37-8(Hazardous Substances Data)

Usage

Description

METHYL 5-(CHLOROMETHYL)-2-FUROATE is a white to yellowish low melting crystalline solid with chemical properties that make it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
METHYL 5-(CHLOROMETHYL)-2-FUROATE is used as an antimicrobial agent for the inhibition of gram-negative bacterial iron uptake. This application is particularly useful in the development of new drugs to combat bacterial infections.
Used in Orthopedic Applications:
METHYL 5-(CHLOROMETHYL)-2-FUROATE is used as a therapeutic agent for the treatment of osteoporosis. Its chemical properties contribute to its potential in enhancing bone density and strength, providing a promising solution for patients suffering from this condition.

InChI:InChI=1/C7H7ClO3/c1-10-7(9)6-3-2-5(4-8)11-6/h2-3H,4H2,1H3

Upstream product

• 611-13-2 2-furoic acid methyl ester 
• 50-00-0 formaldehyd 
• 36802-01-4 Methyl ester of 5-hydroxymethylfuran 2-carboxylic acid 
• 7705-08-0 iron(III) chloride 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 186581-53-3 diazomethane 
• 39238-09-0 5-chloromethyl-2-furancarboxylic acid 
• 61259-48-1 2,3,4,6-tetra-O-acetyl-D-glucono-1,5-lactone 
• 83598-30-5 1,5-di(5-carboxyfuran-2-yl)-2,4-dioxapentan 
• 2144-38-9 methyl 5-(acetoxymethyl)furan-2-carboxylate 
• 57-48-7 D-Fructose 
• 1623-88-7 5-chloromethylfurfural 
• 22860-23-7 (2R,3S)-2-[(acetyloxy)methyl]-6-oxo-3,6-dihydro-2H-pyran-3,5-diyl diacetate 
• 67-56-1 methanol 

Downstream Products

• 100622-11-5 5-benzoyloximethyl-furan-2-carboxylic acid methyl ester 
• 2144-38-9 methyl 5-(acetoxymethyl)furan-2-carboxylate 
• 39258-67-8 2-Carbonsaeuremethylester-5-cyanomethylfuran 
• 24653-40-5 methyl 5-diethylaminomethyl-2-furoate 
• 61834-23-9 methyl 5-(4-methylbenzyl)furan-2-carboxylate 
• 2527-96-0 methyl 5-methyl-2-furancarboxylate 
• 3238-40-2 furan-2,5-dicarboxylic acid 
• 34885-96-6 methyl 5-benzyl-2-furancarboxylate 
• 144268-92-8 5-methoxycarbonyl-2-furfuryl-3-(2-ethyl-6-methyl)dithiocarbazate 
• 81564-51-4 methyl 5-(3,4-dimethoxybenzyl)-2-furoate 
• 81564-52-5 methyl 5-(2,3-dimethoxybenzyl)-2-furoate 
• 60906-88-9 methyl 5-(3,4-dimethylbenzyl)-2-furoate 
• 60906-84-5 methyl 5-(2,3-dimethylbenzyl)-2-furoate 
• 73219-36-0 5-(2-cyano-2-cyclohexylidene-ethyl)-furan-2-carboxylic acid methyl ester 

Relevant articles and documents

Scalable synthesis of hydroxymethyl alkylfuranoates as stable 2,5-furandicarboxylic acid precursors

Hydroxymethyl furanoic acid and its derivatives have been synthesized in high yields and purity from gluconolactone. The reaction sequence allows the recovery of reagents and the use of bio-friendly chemicals and solvents, and can easily be scaled up. The reaction product on a >100 gram scale can be purified by a single purification method, such as distillation or precipitation. The overall yield is above 50%.

SYNTHESIS OF PRECURSORS OF 2,5-FURANDICARBOXYLIC ACID

The present invention relates to a method for the manufacture of stable FDCA precursors from saccharide derived starting materials. More specific the invention relates to the synthesis of FDCA precursors such as alkyl 5-(hydroxymethyl)furan-2-carboxylates or 5-(hydroxymethyl)furan-2-carboxylic acid in an expedient, practical and environmental benign manner from e.g. D-glucono-δ-lactone. These bio-based monomer building blocks hold great potential in the manufacture of polymer materials.

FURAN DERIVATIVES FOR PREVENTING AND CURING OSTEOPOROSIS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The present invention relates to furan derivatives and pharmaceutical compositions containing them to prevent and cure osteoporosis. The furan derivatives of the present invention have effect on bone proliferation with the side effect reduced, so that they can be used for bone disease.