611-13-2Relevant articles and documents
Oxidative esterification of renewable furfural on cobalt dispersed on ordered porous nitrogen-doped carbon
Yin, Defeng,Zheng, Yanxia,Yang, Lixi,Li, Shuyue,Zhu, Daqing,Guo, Yafei,Zuo, Cuncun,Li, Yuchao,Huang, Haofei,Wang, Ming
, p. 3280 - 3287 (2021)
A series of highly dispersed cobalt-based catalysts on N-doped ordered porous carbon (Co-NOPC) were synthesized using the sacrificiallate method. MCM-41, ZSM-5 and SBA-15 were employed as hard templates with 2,2′-bipyridine as the ligand. The physical and
On the nature of the active sites in the selective oxidative esterification of furfural on Au/ZrO2 catalysts
Ampelli,Barbera,Centi,Genovese,Papanikolaou,Perathoner,Schouten,van der Waal
, p. 127 - 134 (2016)
Two catalysts, based on gold on zirconia and prepared in the same way, except for the different thermal treatment in air after the addition of gold (0.4% wt), show a quite different behavior in furfural oxidative esterification, particularly in the select
Ultrahigh-Content Nitrogen-doped Carbon Encapsulating Cobalt NPs as Catalyst for Oxidative Esterification of Furfural
Wang, Ting,Ma, Hong,Liu, Xin,Luo, Yang,Zhang, Shujing,Sun, Yuxia,Wang, Xinhong,Gao, Jin,Xu, Jie
, p. 1515 - 1522 (2019)
It is an attractive and challenging topic to endow non-noble metal catalysts with high efficiency via a nitrogen-doping approach. In this study, a nitrogen-doped carbon catalyst with high nitrogen content encapsulating cobalt NPs (CoOx@N-C(g))
A tunable process: Catalytic transformation of renewable furfural with aliphatic alcohols in the presence of molecular oxygen
Tong, Xinli,Liu, Zonghui,Yu, Linhao,Li, Yongdan
, p. 3674 - 3677 (2015)
The tunable transformation of renewable furfural with aliphatic alcohols in the presence of O2 is developed. Based on a nano Au catalyst and potassium carbonate, a 91.8% yield of methyl 2-furoate with 98.7% selectivity is obtained via the oxidative esterification in a furfural-methanol-O2 system; while a 91.4% yield of 3-(furan-2-yl-)-2-methylacrylaldehyde with 97.2% selectivity is attained via the oxidative condensation in a furfural-n-propanol-O2 system. This journal is
Oxidation of furfural with H2O2 in the presence of a photogenerated iron catalyst
Moulines, Francoise,Ruiz, Jaime,Astruc, Didier
, p. C13 - C14 (1988)
Visible irradiation of a methanolic solution of furfural containing dilute aqueous H2O2 and PF6 (1: R=H, Cl or CH3) as catalyst yields methyl 2-furoate quantitatively.After photodecomplexation, the inorganic FeII,III catalyst can b
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes
Wang, Congcong,Zhang, Yu-Fang,Guo, Shimeng,Zhao, Quan,Zeng, Yanping,Xie, Zhicheng,Xie, Xin,Lu, Boxun,Hu, Youhong
, p. 941 - 957 (2020/11/30)
GPR52 is an orphan G protein-coupled receptor (GPCR) that has been recently implicated as a potential drug target of Huntington's disease (HD), an incurable monogenic neurodegenerative disorder. In this research, we found that striatal knockdown of GPR52 reduces mHTT levels in adult HdhQ140 mice, validating GPR52 as an HD target. In addition, we discovered a highly potent and specific GPR52 antagonist Comp-43 with an IC50 value of 0.63 μM by a structure-activity relationship (SAR) study. Further studies showed that Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. Moreover, in vivo study showed that Comp-43 not only reduces mHTT levels but also rescues HD-related phenotypes in HdhQ140 mice. Taken together, our study confirms that inhibition of GPR52 is a promising strategy for HD therapy, and the GPR52 antagonist Comp-43 might serve as a lead compound for further investigation.
Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols
Bettoni, Léo,Joly, Nicolas,Lohier, Jean-Fran?ois,Gaillard, Sylvain,Poater, Albert,Renaud, Jean-Luc
supporting information, p. 4009 - 4017 (2021/07/02)
The borrowing hydrogen strategy has been applied in the synthesis of nonsymmetric N,N-dialkylated acyl hydrazides via a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex. This strategy represents the first direct one-pot approach to nonsymmetric functionalized acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with a variety of primary or secondary alcohols and methanol or ethanol as alkylating agents in mild reaction conditions and good yields. Deuterium labelling experiments suggested that the primary or secondary alcohol was the hydrogen source in this tandem process. DFT calculations show that the combination of the tandem mixed product cannot be perfectly explained neither structurally nor electronically, but might be dependent of the physical state of the aldehyde or ketone intermediate (gaz vs. liquid) at the reaction temperature. (Figure presented.).