215929-29-6

Basic information

• Product Name: (R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide
• Synonyms: (R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide
• CAS NO: 215929-29-6
• Molecular Weight: 429.602
• Mol File: 215929-29-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide(215929-29-6)
• EPA Substance Registry System: (R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide(215929-29-6)

Safety Data

• Hazardous Substances Data: 215929-29-6(Hazardous Substances Data)

Upstream product

• 53389-98-3 2-(benzyloxy)-5-methylsalicylaldehyde 
• 100-39-0 benzyl bromide 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 215929-27-4 (R)-3-[(R)-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionyl]-4-phenyloxazolidin-2-one 
• 155835-37-3 (4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone 
• 2830-53-7 1-(benzyloxy)-2-bromo-4-methylbenzene 
• 108-18-9 diisopropylamine 
• 215929-28-5 (R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropanoic acid 

Downstream Products

• 124937-51-5 (R)-(+)-tolterodine 

Relevant articles and documents

Rh-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to 3-Arylpropenoates: Enantioselective Synthesis of (R)-Tolterodine

A highly enantioselective conjugate addition of arylboronic acids to 3-arylpropenoates is presented. The rhodium complexes obtained from deoxycholic acid derived binaphthyl phosphites showed good activity as well as very high enantioselectivity (ee up to 99 %) in the conjugate addition to different ethyl-3-arylpropenoates, allowing to obtain useful chiral building blocks for the synthesis of active pharmaceutical ingredients. The method was applied to the enantioselective synthesis of the antimuscarinic drug (R)-tolterodine.