216443-17-3

Basic information

• Product Name: 3'-METHYL [1,1'-BIPHENYL]-2-CARBOXALDEHYDE
• Synonyms: 3'-METHYL[1,1'-BIPHENYL]-2-CARBALDEHYDE;3'-METHYL [1,1'-BIPHENYL]-2-CARBOXALDEHYDE;3'-METHYL-BIPHENYL-2-CARBALDEHYDE;3'-METHYL-BIPHENYL-2-CARBOXALDEHYDE;AKOS BAR-0185;2-(3-Methylphenyl)benzaldehyde
• CAS NO: 216443-17-3
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 196.24
• Mol File: 216443-17-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 338.2 °C at 760 mmHg
• Flash Point: 184.7 °C
• Appearance: /
• Density: 1.074 g/cm³
• CAS DataBase Reference: 3'-METHYL [1,1'-BIPHENYL]-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-METHYL [1,1'-BIPHENYL]-2-CARBOXALDEHYDE(216443-17-3)
• EPA Substance Registry System: 3'-METHYL [1,1'-BIPHENYL]-2-CARBOXALDEHYDE(216443-17-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 216443-17-3(Hazardous Substances Data)

Usage

General Description

3'-Methyl [1,1'-biphenyl]-2-carboxaldehyde is a chemical compound with the molecular formula C14H12O. It is a derivative of biphenyl, an aromatic hydrocarbon. This chemical has a benzaldehyde group, which is a common building block in organic synthesis. It has a strong odor and is used as a flavor and fragrance ingredient. Additionally, it has potential applications in medicinal chemistry and as a starting material for the synthesis of other organic compounds. However, it should be handled with caution as it may pose some health hazards if not used properly.

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Relevant articles and documents

Electrochemical Decarboxylative Cyclization of α-Amino-Oxy Acids to Access Phenanthridine Derivatives

Phenanthridines are a class of useful heterocycles in the field of drug development. In this work, a method via electrochemical decarboxylative cyclization of α-amino-oxy acids to access phenanthridine derivatives was developed. This reaction proceeded th

Palladium-catalyzed synthesis of fluorenes by intramolecular c(sp 2)-h activation at room temperature

The synthesis of fluorenes by intramolecular Pd-catalyzed C(sp 2)-H activation of 2-arylbenzyl chlorides was conducted at room temperature by using commercially available triphenylphosphine and pivalic acid as ligands. The desired reactions proceeded efficiently at room temperature, and various substrates were converted into the corresponding fluorene derivatives in excellent yields.

Low-Valent, High-Spin Chromium-Catalyzed Cleavage of Aromatic Carbon-Nitrogen Bonds at Room Temperature: A Combined Experimental and Theoretical Study

The cleavage of aromatic carbon-nitrogen bonds catalyzed by transition metals is of high synthetic interest because such bonds are common in organic chemistry. However, few metal catalysts can be used to selectively break C(aryl)-N bonds in electronically neutral molecules. We report here the first low-valent, high-spin chromium-catalyzed cleavage of C(aryl)-N bonds in electronically neutral aniline derivatives at room temperature. By using simple and inexpensive chromium(II) chloride as precatalyst, accompanied by an imino auxiliary, the selective arylative and alkylative C-C coupling of C(aryl)-N bonds can be achieved. Crossover experiments indicate that a low-valent chromium species, formed in situ by reduction of CrCl2 with Grignard reagent, is responsible for the catalytic cleavage of C(aryl)-N bonds. DFT calculations show that facile insertion of the C(aryl)-N bond by chromium(0) can take place in a high-spin quintet (S = 2) ground state, whereas the lower-spin singlet (S = 0) and triplet (S = 1) states are inaccessible in energy. It was found that both donation of the sole paired d electrons in the d6 shell of high-spin chromium(0) to the antibonding orbital of the C(aryl)-N bond and the nitrogen ligating interaction to the metal center with its lone pair play important roles in the cleavage of the C(aryl)-N bond by the zerovalent chromium species.