21763-07-5

Basic information

• Product Name: 6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone(SALTDATA: FREE)
• Synonyms: 6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone(SALTDATA: FREE);6,7-DiMethoxy-1,2-dihydroisoquinolin-3(4H)-one
• CAS NO: 21763-07-5
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• Mol File: 21763-07-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 200-202 °C
• Boiling Point: 429.5°Cat760mmHg
• Flash Point: 213.5°C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.537
• PKA: 14.83±0.20(Predicted)
• CAS DataBase Reference: 6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone(SALTDATA: FREE)(21763-07-5)
• EPA Substance Registry System: 6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone(SALTDATA: FREE)(21763-07-5)

Safety Data

• Hazardous Substances Data: 21763-07-5(Hazardous Substances Data)

Usage

General Description

6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone, also known as SALTDATA: FREE, is a chemical compound with molecular formula C11H13NO3. It is a derivative of isoquinoline and contains two methoxy groups on the 6th and 7th positions. 6,7-dimethoxy-1,4-dihydro-3(2H)-isoquinolinone(SALTDATA: FREE) is commonly used in the synthesis of various pharmaceuticals, as well as in research and development. It has potential biological activities and is being studied for its medicinal properties. However, it is important to handle this chemical with care and in accordance with safety protocols due to its potential toxicity.

InChI:InChI=1/C11H13NO3/c1-14-9-3-7-5-11(13)12-6-8(7)4-10(9)15-2/h3-4H,5-6H2,1-2H3,(H,12,13)

Upstream product

• 78222-21-6 3,4-dimethoxy-N-hydroxymethylphenylacetamide 
• 65836-72-8 2-chloro-N-(3,4-dimethoxybenzyl)acetamide 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 340255-41-6 4,5-dimethoxy-2-[(phenylacetamino)methyl]phenylacetic acid 
• 78222-23-8 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide 
• 73053-80-2 ethyl 2-(bromomethyl)-4,5-dimethoxyphenylacetate 
• 16135-41-4 6,7-dimethoxy-3,4-dihydro-1H-2-benzopyran-3-one 
• 50-00-0 formaldehyd 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 100-97-0 hexamethylenetetramine 
• 5663-56-9 2-(3,4-dimethoxyphenyl)acetamide 

Downstream Products

• 75938-11-3 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone 
• 78893-39-7 3-oxo-4-dimethylaminomethylene-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 78893-39-7 4-[1-Dimethylamino-meth-(Z)-ylidene]-6,7-dimethoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 523-02-4 2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinoline 
• 78893-43-3 6,7-Dimethoxy-4-[1-phenethylamino-meth-(Z)-ylidene]-1,4-dihydro-2H-isoquinolin-3-one 

Relevant articles and documents

Regioselectivity in isoquinoline alkaloid synthesis

Regioselectivity in isoquinoline alkaloid synthesis is analyzed here. Our experiments have shown that substituents on the aromatic ring of the starting amine are determinant in isoquinoline synthesis. The use of dicyclohexylcarbodiimide in activating carb

Application of hexamethylenetetramine in a Pictet-Spengler type reaction for synthesis of isoquinoline derivatives

Hexamethylenetetramine was used successfully as amino- and amidoalkylation cyclization reagent for the synthesis of 3,4-dihydroisoquinolines, tetrahydroisoquinolines and 1,4-dihydro-3(2H)-isoquinolinones. The reagent provides a simple and convenient pathway for the preparation of a range of these compounds.

A NEW SYNTHESIS OF 1,4-DIHYDRO-3(2H)-ISOQUINOLINONES BY THE CYCLIZATION OF N-HYDROXYMETHYLARYLACETAMIDES

A new and facile synthesis of 1,4-dihydro-3(2H)-isoquinolinones by the intramolecular amidomethylation with pyrophosphoric acid is described.