218144-97-9

Basic information

• Product Name: N'-(benzo[d][1,3]dioxol-5-ylmethylene)-4-methylbenzenesulfonohydrazide
• Synonyms: N'-(benzo[d][1,3]dioxol-5-ylmethylene)-4-methylbenzenesulfonohydrazide
• CAS NO: 218144-97-9
• Molecular Weight: 318.353
• Mol File: 218144-97-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N'-(benzo[d][1,3]dioxol-5-ylmethylene)-4-methylbenzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(benzo[d][1,3]dioxol-5-ylmethylene)-4-methylbenzenesulfonohydrazide(218144-97-9)
• EPA Substance Registry System: N'-(benzo[d][1,3]dioxol-5-ylmethylene)-4-methylbenzenesulfonohydrazide(218144-97-9)

Safety Data

• Hazardous Substances Data: 218144-97-9(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 495-76-1 piperonol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 4439-02-5 3,4-methylenedioxyphenylacetonitrile 
• 942506-11-8 methyl 2-(benzo[d][1,3]dioxol-5-ylmethyl)benzoate 
• 1606128-18-0 3-(benzo[d][1,3]dioxol-5-yl)-5-chloro-1H-indazole 
• 120-57-0 piperonal 
• 40804-81-7 2-(benzo[d][1,3]dioxol-5-yl)-1-phenylethan-1-one 

Relevant articles and documents

Palladium-Catalyzed Three-Component Coupling Reaction of o-Bromobenzaldehyde, N-Tosylhydrazone, and Methanol

A ligand-controlled palladium-catalyzed three-component reaction of o-bromobenzaldehyde, N-tosylhydrazone, and methanol is described. This reaction uses readily available compounds as starting materials while displaying a broad substrate scope and good functional group compatibility.

Synthesis of Di- and Triarylmethanes through Palladium-Catalyzed Reductive Coupling of N -Tosylhydrazones and Aryl Bromides

A palladium-catalyzed reductive coupling between N-tosylhydrazones and aryl bromides has been developed. The reaction provides an efficient method for the synthesis of diarylmethanes and triarylmethanes via the formation of C(sp2)-C(sp3) single bonds. This new methodology for the synthesis of diarylmethanes and triarylmethanes is featured by the ready availability of the starting materials, mild reaction conditions, and the tolerance of wide range of functional groups. The reaction follows a pathway including palladium carbene formation, migratory insertion, and reduction of the alkylpalladium(II) intermediate.

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker

Target-identification phenotypic screening has been a powerful approach in drug discovery; however, it is hindered by difficulties in identifying the underlying cellular targets. To address this challenge, we have combined phenotypic screening of a fully functionalized small-molecule library with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits. Using this approach, we identified ANXA2, PDIA3/4, FLAD1, and NOS2 as primary cellular targets of two bioactive molecules that inhibit cancer cell proliferation. We further demonstrated that a panel of probes can label and/or image annexin A2 (a cancer biomarker) from different cancer cell lines, thus providing opportunities for potential cancer diagnosis and therapy.