2183-83-7Relevant articles and documents
Pd(0)-Catalyzed Direct Inter- And Intramolecular C-H Functionalization of 4-Carboxyimidazoles
Frippiat, Steven,Peresson, Antoine,Perse, Thibaut,Ramondenc, Yvan,Schneider, Cédric,Querolle, Olivier,Angibaud, Patrick,Poncelet, Virginie,Meerpoel, Lieven,Levacher, Vincent,Bischoff, Laurent,Baudequin, Christine,Hoarau, Christophe
supporting information, p. 1015 - 1021 (2020/06/17)
The palladium-catalyzed arylation and alkenylation of N -substituted methyl imidazole-4-carboxylates are described through inter- and intramolecular pathways. Both direct C2-H and C5-H arylation and alkenylation proceed under Pd(0)/Cu(I) cooperative catal
Imidazole derivatives as PDE10A enzyme inhibitors
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Page/Page column 10, (2012/06/01)
This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr
Intramolecular homolytic substitution at the sulfur atom: an alternative way to generate phosphorus- and sulfur-centered radicals
Carta, Paola,Puljic, Nicolas,Robert, Carine,Dhimane, Anne-Lise,Ollivier, Cyril,Fensterbank, Louis,Lac?te, Emmanuel,Malacria, Max
experimental part, p. 11865 - 11875 (2009/04/06)
Two efficient procedures involving tin hydride or thiophenol-mediated intramolecular homolytic substitution at the sulfur atom are reported. They lead to the generation of varied P(V)-centered radicals from the corresponding aryl or alkyne thiophosphorus substrates. The radical formed can be trapped by an olefin via an intermolecular addition, leading to the construction of C-P bonds. Thiophosphination of triple bonds was also achieved using a radical cycloisomerization process. Extension of the methodology to sulfur-containing species was examined.