218457-73-9Relevant articles and documents
Synthesis method of (S)-2, 6-diamino-5-oxohexanoic acid
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Paragraph 0008, (2021/04/14)
The invention relates to a synthetic method of (S)-2, 6-diamino-5-oxohexanoic acid. The method mainly solves the technical problem of large-scale production of (S)-2, 6-diamino-5-oxohexanoic acid. The synthesis method comprises the following steps: reacting L-2-amino adipic acid with 9-fluorenylmethyl-N-succinimido carbonate in a mixed solution of water and acetone to generate a compound 1; under the catalysis of p-toluenesulfonic acid, reacting the compound 1 with paraformaldehyde in a toluene solution to generate a compound 2; reacting the compound 2 with di-tert-butyl dicarbonate, pyridine and ammonium carbonate in an ethyl acetate solution at room temperature to generate a compound 3; and reacting the compound 3 with lithium hydroxide in a mixed solution of ethanol and water to generate a target compound 4. As a derivative of (S)-2-amino adipic acid, (S)-2, 6-diamino-5-oxo hexanoic acid has become an important intermediate for the synthesis of alpha-amino adipic acid peptide.
Pd-Catalyzed Highly Chemo- And Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid
Ren, Wenlong,Chu, Jianxiao,Sun, Fei,Shi, Yian
supporting information, p. 5967 - 5970 (2019/08/26)
An efficient Pd-catalyzed hydrocarboxylation of alkenes with HCOOH is described. A wide variety of linear carboxylic acids bearing various functional groups can be obtained with excellent chemo- and regioselectivities under mild reaction conditions. The reaction process is operationally simple and requires no handling of toxic CO.
