218787-57-6Relevant articles and documents
Curtius degradation in solid-phase synthesis
Richter, Lutz S.,Andersen, Stina
, p. 8747 - 8750 (1998)
An optimized and broadly applicable procedure for the solid-phase synthesis of primary amines and carbamates via Curtius-degradation of carboxylic acids has been developed. The targeted primary amines and carbamates were obtained in excellent purity and high overall yields.
An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media
Gawande, Manoj B.,Branco, Paula S.
supporting information; experimental part, p. 3355 - 3359 (2012/01/06)
A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles.
