22089-12-9Relevant articles and documents
Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization
Hayakawa, Ichiro,Shioda, Shuya,Chinen, Takumi,Hatanaka, Taisei,Ebisu, Haruna,Sakakura, Akira,Usui, Takeo,Kigoshi, Hideo
, p. 5639 - 5645 (2016)
We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50?=?2.1?μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiments of O6-benzyl glaziovianin A and revealed that O6-benzyl glaziovianin A binds to the colchicine binding site with high affinity. It is interesting that glaziovianin A derivatives change their mode of action in benzylation at the O6(α,β-tubulin inhibitor) or O7(γ-tubulin-specific inhibitor) position.
Method For Producing Low Molecular Weight Aromatic Lignin-Derived Compounds
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Paragraph 0324, (2019/04/08)
The present invention relates to a method for producing one or more low molecular weight aromatic lignin-derived compounds. The method preferably comprises providing lignocellulosic material, subjecting the lignocellulosic material to a pulping process, separating pulp to provide a substantially pulp-free process stream comprising a modified lignin-derived component, isolating the modified lignin-derived component, subjecting the isolated modified lignin-derived component to a decomposition step comprising oxidative cracking (cracking and oxidizing) or reducing under the influence of a catalyst or electro-oxidation, and subjecting the resulting products to an isolation step, to provide a low molecular weight aromatic lignin-derived compound. Said compound may be further modified, e.g. by annulation. The inventive method preferably comprises further oxidizing said compound to a redox active compound. Additionally, the present invention relates to compounds obtainable by the inventive method and to an assembly for carrying out the inventive method. Furthermore, the present invention refers to a method for providing an existing pulp and/or paper manufacturing plant with said assembly.
Micro tube polymn. inhibitor (by machine translation)
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Paragraph 0057-0060, (2018/10/10)
PROBLEM TO BE SOLVED: micro tube polymn. inhibitory activity, as of cytokinetic promisingness. SOLUTION: compd. eq. (I) or pharmaceutically acceptable salt thereof is represented. (A cycloalkyl group, an aryl group, an alkyl or heterocyclyl group; R1, an alkenyl group, an alkynyl group or aryl alkyl group; m is an integer) selected drawing 1-8:no (by machine translation)