52249-88-4

Basic information

• Product Name: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-
• Synonyms: Ethanone,1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]
• CAS NO: 52249-88-4
• Molecular Formula: C16H16O4
• Molecular Weight: 272.301
• Mol File: 52249-88-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 151°C
• CAS DataBase Reference: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-(52249-88-4)
• EPA Substance Registry System: Ethanone, 1-[2-hydroxy-4-methoxy-5-(phenylmethoxy)phenyl]-(52249-88-4)

Safety Data

• Hazardous Substances Data: 52249-88-4(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of benzyl bromide on 2,5-di-hydroxy-4-methoxyacetophenone with potassium carbonate in boiling acetone (67%).

Upstream product

• 22089-12-9 2,5-dihydroxy-4-methoxyacetophenone 
• 100-39-0 benzyl bromide 
• 1818-27-5 1-(2,4,5-trihydroxyphenyl)ethanone 
• 100-44-7 benzyl chloride 
• 69470-86-6 1-(5-acetoxy-2-hydroxy-4-methoxy-phenyl)-ethanone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 82298-06-4 2'-Hydroxy-3,5'-dibenzyloxy-4,4'-dimethoxychalkone 
• 202922-79-0 6-benzyloxy-7-methoxychromone 
• 118793-59-2 5'-benzyloxy-2'-hydroxy-3,4,4'-trimethoxychalkone 
• 79492-56-1 2-(3',4',5'-trimethoxy)benzoyloxy-5-benzyloxy-4-methoxyacetophenone 
• 89635-10-9 1-(5-Benzyloxy-2-hydroxy-4-methoxyphenyl)-3-(2,5-dibenzyloxy-3,4-dimethoxyphenyl)-2-propen-1-on 
• 89635-09-6 1-(5-Benzyloxy-2-hydroxy-4-methoxyphenyl)-3-(2,5-dibenzyloxy-4-methoxyphenyl)-2-propen-1-on 
• 82298-09-7 4',5-dibenzyloxy-2'-hydroxy-3,4',6-trimethoxychalcone 
• 69616-72-4 1-(5-benzyloxy-2,4-dimethoxy-phenyl)-ethanone 
• 118793-60-5 6-benzyloxy-7,3',4'-trimethoxyflavone 

Relevant articles and documents

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50?=?2.1?μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiments of O6-benzyl glaziovianin A and revealed that O6-benzyl glaziovianin A binds to the colchicine binding site with high affinity. It is interesting that glaziovianin A derivatives change their mode of action in benzylation at the O6(α,β-tubulin inhibitor) or O7(γ-tubulin-specific inhibitor) position.

Studies on the metabolism of propafenone. 1st comm.: Synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances

The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-ω-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.