220939-72-0

Basic information

• Product Name: 3-Bromo-4-chlorofuro[3,2-c]pyridine
• Synonyms: 3-Bromo-4-chlorofuro[3,2-c]pyridine
• CAS NO: 220939-72-0
• Molecular Formula: C₇H₃BrClNO
• Molecular Weight: 232.464
• Product Categories: Heterocycle-Pyridine series
• Mol File: 220939-72-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 305.519°C at 760 mmHg
• Flash Point: 138.573°C
• Appearance: /
• Density: 1.82g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Bromo-4-chlorofuro[3,2-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-chlorofuro[3,2-c]pyridine(220939-72-0)
• EPA Substance Registry System: 3-Bromo-4-chlorofuro[3,2-c]pyridine(220939-72-0)

Safety Data

• Hazardous Substances Data: 220939-72-0(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-chlorofuro[3,2-c]pyridine is a chemical compound with the molecular formula C5H2BrClNO. It is a heterocyclic organic compound that consists of a furo[3,2-c]pyridine ring with bromine and chlorine substituents at the 3 and 4 positions, respectively. This chemical is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also employed in research and development as a precursor for the development of new compounds with potential medicinal and agricultural applications. The characteristics and properties of 3-Bromo-4-chlorofuro[3,2-c]pyridine make it a valuable and versatile chemical in the field of organic chemistry.

InChI:InChI=1/C7H3BrClNO/c8-4-3-11-5-1-2-10-7(9)6(4)5/h1-3H

Upstream product

• 31270-80-1 4-chlorofuro[3,2-c]pyridine 
• 92404-70-1 3-bromofuro<3,2-c>pyridine 
• 220939-57-1 3-bromo-furo[3,2-c]pyridine 5-oxide 
• 26956-43-4 5H-furo[3,2-c]pyridin-4-one 
• 59898-36-1 (E)-3-Furan-2-yl-acryloyl azide 
• 29080-01-1 β-(2-Furan)-vinylisocyanat 
• 539-47-9 3-(2-furyl)acrylic acid 
• 98-01-1 furfural 

Downstream Products

• 799293-74-6 4-amino-3-(4-aminophenyl)-furo[3,2-c]pyridine 
• 799293-76-8 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-furo[3,2-c]pyridine 
• 799293-78-0 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-7-bromo-furo[3,2-c]pyridine 
• 1609581-30-7 3-bromo-4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]furo[3,2-c]pyridine 
• 799293-73-5 3-bromofuro[3,2-c]pyridin-4-ylamine 
• 1571111-34-6 6-(4-aminofuro[3,2-c]pyridin-3-yl)-N-phenyl-1-naphthalenecarboxamide 

Relevant articles and documents

Furopyridines. XXVIII. Reactions of 3-bromo derivatives of furo[2,3-b]- , -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine and their N-oxides

Bromination of 3-bromofuro[2,3-b]- 1a, -[3,2-b]- lb and - [3,2- c]pyridine ld afforded the 2,3-dibromo derivatives 2a, 2b and 2d, while the - [2,3-c]- compound lc did not give the dibromo derivative. Nitration of 1a-d gave the 2-nitro-3-bromo compounds 3a-d. The N-oxides 4a-d of 1a-d were submitted to the cyanation with trimethylsilyl cyanide to yield the corresponding α-cyanopyridine compound 6a-d. Chlorination of 4a and 4d with phosphorus oxychloride gave mainly the chloropyridine derivatives 7a, 7'a and 7d, while 4b and 4c gave mainly the chlorofuran derivatives 7(b) and 7(c) accompanying formation of the chloropyridine derivatives 7b, 7'b and 7c. Acetoxylation of 4a and 4b with acetic anhydride yielded the acetoxypyridine compounds 8a, 8'a and 8b, while 4c and 4d gave the acetoxypyridine 8'c, 8'd and 8(d), pyridone 8c and 8d, acetoxyfuran 8(c) and dibromo compound 9c and 9'c.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.