799293-73-5

Basic information

• Product Name: 3-bromofuro[3,2-c]pyridin-4-amine
• Synonyms: 3-bromofuro[3,2-c]pyridin-4-amine;Furo[3,2-c]pyridin-4-aMine, 3-broMo-
• CAS NO: 799293-73-5
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213
• Mol File: 799293-73-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3-bromofuro[3,2-c]pyridin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromofuro[3,2-c]pyridin-4-amine(799293-73-5)
• EPA Substance Registry System: 3-bromofuro[3,2-c]pyridin-4-amine(799293-73-5)

Safety Data

• Hazardous Substances Data: 799293-73-5(Hazardous Substances Data)

Usage

General Description

3-bromofuro[3,2-c]pyridin-4-amine is a chemical compound with the molecular formula C8H6BrN3O. It is a heterocyclic compound containing a furo[3,2-c]pyridine ring system with a bromo group at the 3-position and an amine group at the 4-position. 3-bromofuro[3,2-c]pyridin-4-amine is of interest in the field of medicinal chemistry due to its potential biological and pharmacological activities. Its unique structure makes it a valuable building block for the synthesis of various drug molecules and pharmacologically active compounds. It has the potential to be used in the development of new pharmaceutical drugs, especially those targeting diseases related to the central nervous system or other biological pathways. Further studies and research are needed to explore its full potential and applications in drug discovery and development.

Upstream product

• 31270-80-1 4-chlorofuro[3,2-c]pyridine 
• 29080-01-1 β-(2-Furan)-vinylisocyanat 
• 539-47-9 3-(2-furyl)acrylic acid 
• 26956-43-4 5H-furo[3,2-c]pyridin-4-one 
• 59898-36-1 (E)-3-Furan-2-yl-acryloyl azide 
• 98-01-1 furfural 
• 220939-72-0 4-chloro-3-bromofuro<3,2-c>pyridine 

Downstream Products

• 799293-76-8 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-furo[3,2-c]pyridine 
• 799293-78-0 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-7-bromo-furo[3,2-c]pyridine 
• 1571111-34-6 6-(4-aminofuro[3,2-c]pyridin-3-yl)-N-phenyl-1-naphthalenecarboxamide 
• 799293-74-6 4-amino-3-(4-aminophenyl)-furo[3,2-c]pyridine 

Relevant articles and documents

N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Discovery of a new series of naphthamides as potent VEGFR-2 kinase inhibitors

Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of cancer. In this study, we describe the design, synthesis, and biological evaluation of a new series of naphthamides as potent inhibitors of VEGFR-2. Among these compounds, 14c exhibited high VEGFR-2 inhibitory potency in both enzymatic and HUVEC cellular proliferation assays, with IC50 values of 1.5 and 0.9 nM, respectively. Kinase selectivity profiling revealed that 14c was a multitargeted inhibitor, and it also exhibited good potency against VEGFR-1, PDGFR-β, and RET. Furthermore, 14c effectively blocked tube formation of HUVEC at nanomolar level. Overall, 14c might be a promising candidate for the treatment of cancer.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.