221325-35-5

Basic information

• Product Name: chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane
• Synonyms: chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane
• CAS NO: 221325-35-5
• Molecular Weight: 257.792
• Mol File: 221325-35-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane(221325-35-5)
• EPA Substance Registry System: chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane(221325-35-5)

Safety Data

• Hazardous Substances Data: 221325-35-5(Hazardous Substances Data)

Upstream product

• 144467-97-0 (α,α-dimethylbenzyl)dimethylsilanol 
• 118740-38-8 chloro(α,α-dimethylbenzyl)dimethylsilane 
• 221325-34-4 (α,α-dimethyl-4-nitrobenzyl)dimethylsilanol 

Downstream Products

• 221325-37-7 N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester 
• 301843-66-3 N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester 
• 301843-67-4 N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester 
• 221325-44-6 N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl]-L-serine allyl ester 
• 221325-43-5 N-(9-fluorenylmethoxycarbonyl)-O-[(4-amino-α,α-dimethylbenzyl)dimethylsilyl]-L-serine allyl ester 
• 301843-72-1 N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester 
• 301843-71-0 N-(9-fluorenylmethoxycarbonyl)-O-[2-acetamido-2-deoxy-3,4-O-isopropylidene-6-O-(α,α-dimethyl-4-aminobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester 
• 221325-38-8 N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-threonine allyl ester 
• 248927-82-4 N-(9-fluorenylmethoxycarbonyl)-O-[2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-6-O-(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl-α-D-galactopyranosyl]-L-threonine allyl ester 

Relevant articles and documents

Design and synthesis of silyl ether-based linker for solid-phase synthesis of glycopeptides

A novel silyl linker was designed to facilitate the solid-phase synthesis of protected glycopeptide blocks. Alcohols (carbohydrate, serine, or threonine) were silylated with trialkylchlorosilane containing the p- nitrophenyl group. The nitro group was reduced and succinylated to give the succinanilic acids, which were attached to the glycine-preloaded resin via activation with HBTU/HOBt. After elongation of the peptide chain by segment condensation of Fmoc chemistry-based stepwise method, the synthesized glycopeptides in the protected form were split from the resin by fluoridolysis.