221458-86-2

Basic information

• Product Name: Methanone, phenyl[2-(phenylethynyl)phenyl]-
• CAS NO: 221458-86-2
• Molecular Formula: C21H14O
• Molecular Weight: 282.342
• Mol File: 221458-86-2.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl[2-(phenylethynyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl[2-(phenylethynyl)phenyl]-(221458-86-2)
• EPA Substance Registry System: Methanone, phenyl[2-(phenylethynyl)phenyl]-(221458-86-2)

Safety Data

• Hazardous Substances Data: 221458-86-2(Hazardous Substances Data)

Upstream product

• 776-75-0 N-benzoylpiperidine 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 591-50-4 iodobenzene 
• 308378-45-2 (2-ethynylphenyl)(phenyl)methanone 
• 13047-06-8 o-bromobenzophenone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 117-99-7 2-Hydroxybenzophenone 
• 512787-24-5 2-benzoylphenyl trifluoromethanesulfonate 
• 536-74-3 phenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 591-51-5 phenyllithium 
• 383909-10-2 tributyl[2-(2-phenylethynyl)phenyl]stannane 
• 98-88-4 benzoyl chloride 

Downstream Products

• 64075-43-0 5,10,11-triphenyl-11H-benzofluorene 
• 1263056-83-2 1-(2-(2-(cyclopropylidene(phenyl)methyl)phenyl)ethynyl)benzene 
• 115101-39-8 1,2-dihydro-3,8-diphenylcyclopenta[a]indene 
• 1309688-76-3 C₂₈H₁₄F₅NO₂ 
• 1309688-95-6 C₂₇H₁₉N 
• 1309688-96-7 C₂₈H₂₁N 
• 1309688-98-9 C₂₈H₁₈F₃N 
• 1309689-02-8 C₂₁H₁₅NO 
• 78602-40-1 1-benzylidene-3-phenyl-1H-isoindole 
• 1259017-35-0 1-(phenylethynyl)-2-(1-phenylvinyl)benzene 

Relevant articles and documents

A Mild and Regioselective Synthesis of α-Fluoroketones via Gold and Selectfluor Partnership

An efficient, mild and rapid synthesis of α-fluoroketones has been developed, via a fruitful association between gold and Selectfluor starting from aldehyde-yne and alkynylaryl ketone derivatives. Several functionalized and synthetically highly valuable α-fluoroketones (21 compounds, up to 92%) were isolated in good to excellent yields via a remarkable regioselective oxyfluorination reaction in EtOH/H2O at room temperature. We have shed some light on parts of the mechanism by reacting diphenylacetylene and aldehyde-yne with or without Selectfluor. The reaction most presumably occurs via a sequential gold-catalyzed regioselective hydration followed by the α-fluorination reaction, but the presence of aldehyde moiety is crucial for the reactivity of alkyne function. The fluoroketones were efficiently transformed to 4-fluoroisoquinolines (9 compounds, 82–95%) of high pharmaceutical interest. (Figure presented.).

Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis

The first asymmetric hydrogenation of in situ generated isochromenylium derivatives is enabled by tandem catalysis with a binary system consisting of Cu(OTf)2 and a chiral cationic ruthenium–diamine complex. A range of chiral 1H-isochromenes were obtained in high yields with good to excellent enantioselectivity. These chiral 1H-isochromenes could be easily transformed into isochromanes, which represent an important structural motif in natural products and biologically active compounds. The chiral induction was rationalized by density functional theory calculations.

Iodine-Mediated Cyclization of ortho-Alkynylaryl Ketones for the Synthesis of Indenone Derivatives

A new method for the synthesis of indenone derivatives based on the I2-promoted cyclization of ortho-alkynylaryl ketones has been developed. This method provides a metal-free and convenient route for the regioselective synthesis of indenones using ortho-alkynylaryl ketones with predefined substituents to give indenone products in moderate to good yields.