22148-77-2

Basic information

• Product Name: 1-METHYL-3-PHENYLPROPYLAMINE
• Synonyms: RARECHEM AN KC 0213;1-METHYL-3-PHENYLPROPYLAMINE;ALPHA-METHYL-3-PHENYLPROPYLAMINE;(3-AMINOBUTYL)-BENZENE;(+/-)-3-AMINO-1-PHENYLBUTANE;3-AMINO-1-PHENYLBUTANE;4-PHENYL-2-BUTYLAMINE;AURORA KA-7767
• CAS NO: 22148-77-2
• Molecular Formula: C10H15N
• Molecular Weight: 149.23
• EINECS: 244-942-2
• Mol File: 22148-77-2.mol
• Article Data: 136

Chemical Properties

• Melting Point: -50 °C
• Boiling Point: 228-232 °C(lit.)
• Flash Point: 208 °F
• Appearance: /
• Density: 0.922 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.105mmHg at 25°C
• Refractive Index: n20/D 1.514(lit.)
• CAS DataBase Reference: 1-METHYL-3-PHENYLPROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-PHENYLPROPYLAMINE(22148-77-2)
• EPA Substance Registry System: 1-METHYL-3-PHENYLPROPYLAMINE(22148-77-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 2
• RTECS: UI3920000
• Hazardous Substances Data: 22148-77-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-3-phenylpropylamine is a chemical compound that belongs to the class of organic compounds known as beta amino acids and derivatives. These compounds contain an amino acid or a derivative thereof which bears an amino group at the beta-position, as well as the characteristic feature of being non-polar and lipid-like. It also contains an amine functional group. It has a role as a human metabolite. Detailed information regarding its applications and toxicity levels is not widely available, indicating that it is primarily used in professional, scientific and technical activities, such as scientific research or substances manufacture.

InChI:InChI=1/C10H15N/c1-3-10(2,11)9-7-5-4-6-8-9/h4-8H,3,11H2,1-2H3

Upstream product

• 2887-98-1 benzalacetone oxime 
• 2550-26-7 4-Phenyl-2-butanone 
• 540-69-2 ammonium formate 
• 7664-41-7 ammonia 
• 1896-62-4 (E)-benzalacetone 
• 36894-69-6 labetaol 
• 202123-10-2 (4-Chloro-benzyl)-[1-methyl-3-phenyl-prop-(E)-ylidene]-amine 
• 910213-03-5 (S)-4-phenylbutan-2-yl isocyanide 
• 101507-04-4 tert-butyl (4-phenylbutan-2-yl)carbamate 
• 2344-70-9 (+)-(S)-4-phenylbutan-2-ol 
• 148065-57-0 C₁₈H₂₁N 
• 68164-04-5 N-benzyl-1-methyl-3-phenylpropylamine 
• 22374-89-6 (RS)-1-methyl-3-phenylpropylamine 
• 57461-27-5 N-benzoylglycine 2,2,2-trifluoroethyl ester 

Downstream Products

• 433236-68-1 (1-methyl-3-phenyl-propyl)-oxalamic acid ethyl ester 
• 98609-02-0 N-<β-(3-indolyl)ethyl>-N'-(1-methyl-3-phenyl)propyl-1,3-diamino-2-propanol 
• 103849-26-9 3-(2,4-Dihydroxy-phenyl)-N-(1-methyl-3-phenyl-propyl)-3-phenyl-propionamide 
• 103849-22-5 3-(2,3-Dihydroxy-phenyl)-N-(1-methyl-3-phenyl-propyl)-3-phenyl-propionamide 
• 4187-57-9 (S)-1-methyl-3-phenylpropylamine 
• 937-52-0 (R)-1-methyl-3-phenylpropylamine 
• 22148-79-4 (R)-N-(4-phenylbutan-2-yl)ethanamide 
• 1100753-83-0 N-(((S)-4-phenylbutan-2-ylcarbamoyl)methyl)octanamide 
• 1222802-29-0 2-ethanamido-3-phenyl-N-(4-phenylbutan-2-yl)propanamide 
• 1222802-32-5 N-(2-oxo-2-(4-phenylbutan-2-ylamino)ethyl)-8-phenyloctanamide 
• 1222802-25-6 2-ethanamido-N-(4-phenylbutan-2-yl)ethanamide 
• 1100753-76-1 2-ethanamido-N-(4-phenylbutan-2-yl)ethanamide 
• 1222802-26-7 N-(2-oxo-2-(4-phenylbutan-2-ylamino)ethyl)benzamide 
• 1100753-77-2 N-(2-oxo-2-(4-phenylbutan-2-ylamino)ethyl)benzamide 

Relevant articles and documents

Stereo-Divergent Enzyme Cascades to Convert Racemic 4-Phenyl-2-Butanol into either (S)- or (R)-Corresponding Chiral Amine

The synthesis of enantiopure chiral amines from racemic alcohols is a key transformation in the chemical industry, e. g., in the production of active pharmaceutical ingredients (APIs). However, this reaction remains challenging. In this work, we propose a one-pot enzymatic cascade for the direct conversion of a racemic alcohol into either (S)- or (R)-enantiomers of the corresponding amine, with in-situ cofactor recycling. This enzymatic cascade consists of two enantio-complementary alcohol dehydrogenases, both NADH and NADPH oxidase for in-situ recycling of NAD(P)+ cofactors, and either (S)- or (R)-enantioselective transaminase. This cell-free biocatalytic system has been successfully applied to the conversion of racemic 4-phenyl-2-butanol into the high value (S)- or (R)-enantiomers of the amine reaching good (73 % (S)) and excellent (>99 % (R)) enantioselectivities.

Two-Step Protocol for Iodotrimethylsilane-Mediated Deoxy-Functionalization of Alcohols

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcohols to afford products containing a C?N, C?S, or C?O bond. In the first step the alcohol undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-molecule drugs containing hydroxy-group.

3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF

The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (I) : wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is useful as a prophylact