221670-72-0

Basic information

• Product Name: (R)-4-(1-AMINOETHYL)PHENOL
• Synonyms: 4-[(1R)-1-AMINOETHYL]PHENOL;(R)-4-(1-AMINOETHYL)PHENOL;Phenol, 4-[(1S)-1-aminoethyl]- (9CI);Phenol, 4-[(1S)-1-aminoethyl]-;S-4-Hydroxy-α-methylbenzylamine
• CAS NO: 221670-72-0
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Product Categories: ALCOHOL;chiral
• Mol File: 221670-72-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 252.2±15.0 °C(Predicted)
• Appearance: Off-white/Solid
• Density: 1.096±0.06 g/cm3(Predicted)
• PKA: 10.20±0.26(Predicted)
• CAS DataBase Reference: (R)-4-(1-AMINOETHYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(1-AMINOETHYL)PHENOL(221670-72-0)
• EPA Substance Registry System: (R)-4-(1-AMINOETHYL)PHENOL(221670-72-0)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 221670-72-0(Hazardous Substances Data)

Usage

Uses

(S)-4-(1-Aminoethyl)phenol is used as an intermediate in organic synthesis.

Upstream product

• 134855-87-1 α-methyl-p-hydroxybenzylamine 
• 6298-96-0 (S)-1-(4-methoxyphenyl)ethylamine 
• 917911-59-2 (S)-1-(4-tert-butoxyphenyl)ethylamine sulfate 

Downstream Products

• 931093-42-4 (S)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate 
• 1362627-27-7 C₂₂H₃₀N₂O₄ 
• 645391-89-5 benzyl N-[(1S)-1-(4-hydroxyphenyl)ethyl]carbamate 
• 1620690-56-3 (R)-tert-butyl 3-(4-((S)-1-(benzyloxycarbonylamino)ethyl)phenoxy)pyrrolidine-1-carboxylate 

Relevant articles and documents

Deracemization of Racemic Amines to Enantiopure (R)- and (S)-amines by Biocatalytic Cascade Employing ω-Transaminase and Amine Dehydrogenase

A one-pot deracemization strategy for α-chiral amines is reported involving an enantioselective deamination to the corresponding ketone followed by a stereoselective amination by enantiocomplementary biocatalysts. Notably, this cascade employing a ω-transaminase and amine dehydrogenase enabled the access to both (R)-and (S)-amine products, just by controlling the directions of the reactions catalyzed by them. A wide range of (R)-and (S)-amines was obtained with excellent conversions (>80 %) and enantiomeric excess (>99 % ee). Finally, preparative scale syntheses led to obtain enantiopure (R)- and (S)-13 with the isolated yields of 53 and 75 %, respectively.

PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical

METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALKYLPHENOLS

The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R).