6298-96-0

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-ETHYLAMINE
• Synonyms: TIMTEC-BB SBB007015;1-ANISYLETHYLAMINE;1-(4-METHOXY-PHENYL)-ETHYLAMINE;1-(4-METHOXYPHENYL)ETHANAMINE;1-(P-METHOXYPHENYL)ETHYLAMINE;AKOS B006177;AKOS BC-0984;ART-CHEM-BB B006177
• CAS NO: 6298-96-0
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Product Categories: Aminomethyl's;Phenyls & Phenyl-Het
• Mol File: 6298-96-0.mol
• Article Data: 103

Chemical Properties

• Boiling Point: 240.3 °C at 760 mmHg
• Flash Point: 99.3 °C
• Appearance: /
• Density: 1.003 g/cm³
• Vapor Pressure: 0.0383mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.29±0.10(Predicted)
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-ETHYLAMINE(6298-96-0)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-ETHYLAMINE(6298-96-0)

Safety Data

• Hazard Codes: Xi,C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 6298-96-0(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxy-phenyl)-ethylamine is a chemical compound with the molecular formula C9H13NO. It is an organic compound that consists of a phenethylamine core with a methoxy substituent at the 4-position on the phenyl ring. 1-(4-METHOXY-PHENYL)-ETHYLAMINE is commonly used as a precursor in the synthesis of various pharmaceuticals and research chemicals. It is also used in the production of certain neurotransmitters and as a building block for other complex organic molecules. Additionally, it has potential applications in the development of new medicines and therapies for various medical conditions. Overall, 1-(4-Methoxy-phenyl)-ethylamine is an important chemical with various practical and scientific uses.

InChI:InChI=1/C9H13NO/c1-7(10)8-3-5-9(11-2)6-4-8/h3-7H,10H2,1-2H3

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 64187-51-5 N-trimethylsilyl(4-methoxy)benzaldimine 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 
• 874-90-8 4-methoxybenzonitrile 
• 6298-96-0 (S)-1-(4-methoxyphenyl)ethylamine 
• 1559065-83-6 N-chloro-1-(4-methoxyphenyl)ethanimine 
• 6298-96-0 1(R)-(4-methoxyphenyl)-ethylamine 
• 70249-37-5 3-aminocyclohexa-1,5-dienecarboxylic acid 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 143589-99-5 (1S)-N-benzyloxycarbonyl-1-(4-methoxy-phenyl)ethylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 2475-92-5 (E)-1-(4-methoxyphenyl)ethanone oxime 
• 14429-17-5 anti-N-(α-methyl-4-methoxybenzylidene)benzylamine 

Downstream Products

• 6298-96-0 1(R)-(4-methoxyphenyl)-ethylamine 
• 6298-96-0 (S)-1-(4-methoxyphenyl)ethylamine 
• 281664-25-3 (R)-(+)-N-4-Methoxybenzyl-1-(4-methoxyphenyl)ethylamine 
• 82776-14-5 (S)-N-[1-(4-methoxyphenyl)ethyl]acetamide 
• 856410-19-0 (3S,4R,1'S)-4-methoxycarbonyl-3-trichloroacetylamino-1-[1'-(4''-methoxyphenyl)ethyl]pyrrolidin-2-one 

Relevant articles and documents

Reactivity of chiral exocyclic N-acyliminium ions with aromatic derivatives

Chiral N-acyliminium ions obtained from optically active N-[1-(phenylsulfonyl)alkyl]oxazolidin-2-ones at low temperature in the presence of titanium tetrachloride react with electron-rich aromatic compounds to afford the corresponding adducts in good yields and variable diastereoselectivities. Chemoselective cleavage of the oxazolidin-2-one ring with lithium/ammonia affords the corresponding benzylamines in enantioenriched form. The utilization of 4-benzyloxazolidin-2-one as a chiral auxiliary leads to intramolecular cyclization with exclusive formation of one diastereomer. The obtained tricyclic derivatives possess the core structure of some aza analogs of the anticancer drug podophyllotoxin.

Catalytic asymmetric oxidative carbonylation-induced kinetic resolution of sterically hindered benzylamines to chiral isoindolinones

A highly enantioselective kinetic resolution of sterically hindered benzylamines has been achieved for the first time through transition-metal-catalyzed oxidative carbonylation, in which the new KR strategy offered a new approach to afford chiral isoindolinones (er up to 97?:?3) and the origin of chemoselectivity and stereoselectivity was confirmed by density functional theory (DFT) calculations.

Rapid Synthesis of Primary Amines from Ketones using Choline Chloride/Urea Deep Eutectic as a Reaction Medium

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