22265-77-6

Basic information

• Product Name: 1-(2-ETHYLPHENYL)-2-THIOUREA
• Synonyms: 1-(2-ETHYLPHENYL)-2-THIOUREA;2-ETHYLPHENYLTHIOUREA
• CAS NO: 22265-77-6
• Molecular Formula: C₉H₁₂N₂S
• Molecular Weight: 180.27
• Mol File: 22265-77-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 146-148°C
• Boiling Point: 294 °C at 760 mmHg
• Flash Point: 131.6 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.00167mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 1-(2-ETHYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-ETHYLPHENYL)-2-THIOUREA(22265-77-6)
• EPA Substance Registry System: 1-(2-ETHYLPHENYL)-2-THIOUREA(22265-77-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 22265-77-6(Hazardous Substances Data)

Usage

General Description

1-(2-Ethylphenyl)-2-thiourea is a synthetic, organic chemical compound. It is part of the family of chemicals known as thioureas, which are characterized by the presence of a sulfur atom and a carbonyl group. This chemical is used mainly in the manufacturing of other chemicals and may be utilized as an intermediate in various chemical reactions. However, it should be noted that thioureas are known to have potential for toxicity and may cause adverse health effects upon exposure, thus careful handling and storage are necessary. The exact properties and behaviors of this specific chemical, like its melting point or its boiling point, would require further examination.

InChI:InChI=1/C9H12N2S/c1-2-7-5-3-4-6-8(7)11-9(10)12/h3-6H,2H2,1H3,(H3,10,11,12)

Upstream product

• 88884-36-0 1-benzoyl-3-(2-ethylphenyl)-2-thiourea 
• 578-54-1 ortho-ethylaniline 
• 532-55-8 Benzoyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 139331-68-3 4-ethyl-1,3-benzothiazol-2-amine 
• 412919-79-0 N-(2-ethylphenyl)-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amine 
• 88884-62-2 N-(2-Ethyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 139331-50-3 5-Ethyl-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-4H-benzo[1,4]thiazin-3-one 
• 139331-76-3 2-Amino-3-ethyl-benzenethiol 
• 89069-98-7 1-(2-Ethyl-phenyl)-2-methyl-isothiourea 
• 75276-66-3 1-(2-Ethyl-phenyl)-4,6-dimethyl-1H-pyrimidine-2-thione 
• 75276-66-3 1-(o-ethylphenyl)-4,6-dimethylpyrimidin-2(1H)-thione 

Relevant articles and documents

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nau

Structural requirement(s) of N-phenylthioureas and benzaldehyde thiosemicarbazones as inhibitors of melanogenesis in melanoma B 16 cells

In order to define the structural requirements of phenylthiourea (PTU), a series of thiourea and thiosemicarbazone analogs were prepared and evaluated as inhibitors of melanogenesis in melanoma B16 cells. The most potent analog was 2-(4-tert-butylbenzylidene)hydrazinecarbothioamide (1u) with an IC50 value of 2.7 μM in inhibition of melanogenesis. The structure for potent inhibitory activity of these derivatives are required with the direct connection of π-planar structure to thiourea without steric hinderance in PTU derivatives and the hydrophobic substituent at para position in case of semicarbazones.

Synthesis and biological activities of new 1,4-benzothiazine derivatives

New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.