579476-63-4

Basic information

• Product Name: 2-Methylpyridine-4-boronic acid
• Synonyms: 2-PICOLINE-4-BORONIC ACID;2-METHYLPYRIDINE-4-BORONIC ACID;(2-METHYLPYRIDIN-4-YL)BORONIC ACID;2-METHYL-4-PYRIDINYLBORONIC ACID;2-METHYL-4-PYRIDINEBORONIC ACID;2-METHYL-4-PYRIDINEBORIC ACID;Boronic acid, (2-methyl-4-pyridinyl)- (9CI);4-Borono-2-methylpyridine
• CAS NO: 579476-63-4
• Molecular Formula: C₆H₈BNO₂
• Molecular Weight: 136.94422
• Product Categories: PYRIDINE;Boronic Acid series;Pyridines;Boronic acid;Boric Acid| Boric Acid Ester| Potassium Trifluoroborate
• Mol File: 579476-63-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 311.2 °C at 760 mmHg
• Flash Point: 142 °C
• Appearance: white to light yellow crystal powder
• Density: 1.18 g/cm³
• Vapor Pressure: 0.00042mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 7?+-.0.10(Predicted)
• CAS DataBase Reference: 2-Methylpyridine-4-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylpyridine-4-boronic acid(579476-63-4)
• EPA Substance Registry System: 2-Methylpyridine-4-boronic acid(579476-63-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 579476-63-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 579476-63-4 differently. You can refer to the following data:
1. suzuki reaction
2. (2-Methylpyridin-4-yl)boronic Acid (CAS# 579476-63-4) is used as a reagent in the preparation of dihydro-phenylquinazlinone derivatives as encephalitic alphaviruses inhibitors useful in the treatment of viral infections.

InChI:InChI=1/C6H8BNO3/c1-5-4-6(2-3-8-5)11-7(9)10/h2-4,9-10H,1H3

Upstream product

• 19524-06-2 4-bromopyridine hydrochloride 
• 58530-53-3 2,4-dibromopyridine 
• 22282-99-1 4-bromo-2-methylpyridine 
• 121-43-7 Trimethyl borate 
• 5419-55-6 Triisopropyl borate 
• 660867-80-1 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Downstream Products

• 1161362-06-6 2-(2-methylpyridin-4-yl)-5-nitrobenzonitrile 
• 1161361-82-5 2-(7-(2-methylpyridin-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide 
• 1161361-15-4 (+/-)-2-(3-methyl-5-(2-methylpyridin-4-yl)phenyl)-N-(4-(2-methylpyridin-4-yl)-phenyl)propanamide 
• 1095708-41-0 6-chloro-2-phenyl-3-(2-methylpyrid-4-yl)imidazo[1,2-b]pyridazine 
• 1420199-39-8 5,6,7,8-tetrahydro-8-(2-methylphenyl)-2-[5-(2-methyl-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-[1,2,4]triazolo[1,5-a]pyridine 
• 1443282-45-8 potassium trifluoro(2-methylpyridin-4-yl)borate 
• 1353255-14-7 ethyl 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylate 
• 1366180-79-1 4-hydroxy-2-[4-(2-methylpyridin-4-yl)phenyl]-1,6-naphthyridine-3-carbonitrile 
• 1354554-55-4 3-[4-(2-picoline-4-yl)-benzamidomethyl]-N-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-benzamide 
• 1354355-95-5 N-(2,4-dimethoxybenzyl)-1-(2',5-dimethyl-3,4'-bipyridin-6-yl)methanamine 
• 1354355-43-3 tert-butyl 4-(5-((3-fluoro-4-(2-methylpyridin-4-yl)benzyl)carbamoyl)pyridin-2-yl)piperazine-1-carboxylate 
• 1354355-37-5 (3-fluoro-4-(2-methylpyridin-4-yl)phenyl)methanamine 
• 1354353-63-1 6-(4-acetylpiperazin-1-yl)-N-(3-fluoro-4-(2-methylpyridin-4-yl)benzyl)nicotinamide 
• 1354355-45-5 N-(3-fluoro-4-(2-methylpyridin-4-yl)benzyl)-6-(piperazin-1-yl)nicotinamide 

Relevant articles and documents

NOVEL ORGANIC COMPOUND AND MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES COMPRISING THE SAME AND ORGANIC ELECTROLUMINESCENT DEVICES COMPRISING THE SAME

The present invention provides a novel organic compound represented by chemical formula 1, a material for an organic electroluminescent device including the organic compound, and an organic electroluminescent device. The present invention can improve color purity and device life.

Nickel-catalyzed borylation of halides and pseudohalides with tetrahydroxydiboron [B2(OH)4]

Arylboronic acids are gaining increased importance as reagents and target structures in a variety of useful applications. Recently, the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron (BBA) reagent has been reported. The high cost associated with palladium, combined with several limitations of both palladium- and copper-catalyzed processes, prompted us to develop an alternative method. Thus, the nickel-catalyzed borylation of aryl and heteroaryl halides and pseudohalides using tetrahydroxydiboron (BBA) has been formulated. The reaction proved to be widely functional group tolerant and applicable to a number of heterocyclic systems. To the best of our knowledge, the examples presented here represent the only effective Ni-catalyzed Miyaura borylations conducted at room temperature.

PHOSPHODIESTERASE 4 INHIBITORS

PDE4 inhibition is achieved by novel compounds of the Formula (I) wherein R1 and R2 are as defined herein.